Document Detail


Antiphospholipid antibodies and pregnancy outcomes in women heterozygous for factor V Leiden.
MedLine Citation:
PMID:  20439118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiphospholipid antibodies are associated with a spectrum of pregnancy complications, including preeclampsia and small for gestational age (SGA) fetuses. We sought to assess anticardiolipin and anti-beta2-glycoprotein I (anti-beta2-GPI) IgG and IgM antibody prevalence and the relationship of these antibodies to pregnancy complications in women with the Factor V Leiden (FVL) mutation. The study comprised a secondary analysis of a multicenter, prospective observational study of FVL prevalence among 5188 asymptomatic pregnant women. A subset of 362 women (117 FVL heterozygotes, 245 matched controls) had serum collected at the time of the original study and underwent serum analysis for anticardiolipin and anti-beta2-GPI IgG and IgM as a part of this analysis. The primary outcome was preeclampsia and/or SGA (<10%). The overall prevalence of anticardiolipin and anti-beta2-GPI IgG and IgM antibodies was low and did not vary with FVL status. Forty-seven women (13.0%) developed preeclampsia and/or SGA. There were no differences in primary outcome rates between women with and without aPL antibodies, regardless of FVL mutation status. Among FVL carriers, the presence of antiphospholipid antibodies does not appear to contribute to adverse pregnancy outcome.
Authors:
Tracy Manuck; D Ware Branch; Yinglei Lai; Baha Sibai; Catherine Y Spong; George Wendel; Katharine Wenstrom; Philip Samuels; Steve N Caritis; Yoram Sorokin; Menachem Miodovnik; Mary J O'Sullivan; Deborah Conway; Ronald J Wapner;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-05-02
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  85     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-11-16     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, University of Utah, 30N 1900E, Room 2B200, Salt Lake City, UT 84132, USA. tracy.manuck@hsc.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antiphospholipid / blood
Cardiolipins / immunology
DNA Mutational Analysis
Factor V / genetics*
Female
Fetal Growth Retardation / epidemiology,  genetics*,  immunology*,  physiopathology
Heterozygote
Humans
Immunoglobulin M / blood
Mutation / genetics
Pre-Eclampsia / epidemiology,  genetics*,  immunology*,  physiopathology
Pregnancy
Pregnancy Outcome
Prospective Studies
beta 2-Glycoprotein I / immunology
Grant Support
ID/Acronym/Agency:
HD21410/HD/NICHD NIH HHS; HD21414/HD/NICHD NIH HHS; HD27860/HD/NICHD NIH HHS; HD27861/HD/NICHD NIH HHS; HD27869/HD/NICHD NIH HHS; HD27905/HD/NICHD NIH HHS; HD27915/HD/NICHD NIH HHS; HD27917/HD/NICHD NIH HHS; HD34116/HD/NICHD NIH HHS; HD34122/HD/NICHD NIH HHS; HD34136/HD/NICHD NIH HHS; HD34208/HD/NICHD NIH HHS; HD34210/HD/NICHD NIH HHS; U01-HD36801/HD/NICHD NIH HHS; U10 HD034208-06/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Cardiolipins; 0/Immunoglobulin M; 0/beta 2-Glycoprotein I; 0/factor V Leiden; 9001-24-5/Factor V
Comments/Corrections

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