Document Detail

Antiphospholipid antibodies and pregnancy: maternal implications.
MedLine Citation:
PMID:  2187247     Owner:  NLM     Status:  MEDLINE    
Antiphospholipid antibodies are associated with a spectrum of serious medical conditions. Several of these are of special concern to the obstetrician because they have a tendency to occur during pregnancy. Untreated pregnant women with aPLA appear to be especially prone to thrombotic events, including stroke. Atypically early-onset preeclampsia occurs in a large proportion of women with aPLA and a history of pregnancy loss. Conversely, a modest proportion of women with early-onset preeclampsia have aPLA. Although rare, a syndrome of postpartum pleuropulmonary disease and thrombosis is associated with aPLA. Finally, certain neurologic conditions, such as TIAs and chorea gravidarum, appear to be related to aPLA. It is important to recognize pregnant women with aPLA so they can be appropriately managed in an effort to avoid fetal loss and thromboembolic events.
D W Branch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  14     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-21     Completed Date:  1990-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City.
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MeSH Terms
Autoantibodies / analysis*
Phospholipids / analysis*
Pre-Eclampsia / immunology
Pregnancy / immunology*
Pregnancy Complications / immunology*
Thromboembolism / immunology
Grant Support
Reg. No./Substance:
0/Autoantibodies; 0/Phospholipids

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