Document Detail


Antiphospholipid antibodies impact the protein C (PC) pathway behavior.
MedLine Citation:
PMID:  12353314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiphospholipid antibodies may interfere with the PC pathway, displaying a resistance to the activated PC (resistant phenotype). This effect was evaluated by the APCR and the ProCG systems in 36 lupus anticoagulant samples, yielding abnormal results in 47% of APCR(original), 17% of APCR(modified), and 22% of ProCG test. ProCG values correlated with APCR(original) but not with APCR(modified). Most of lupus anticoagulants affecting the PC pathway showed abnormal APCR(original) results but not abnormal ProCG values. The different behavior between both systems may be due to the heterogeneity of the antibodies or could be attributed to the fact that, in the ProCG, a PC activator is added, while the APCR employs already activated exogenous PC.
Authors:
Laura C Gennari; Alicia N Blanco; María Fabiana Alberto; Silvia H Grosso; Andrea A Peirano; Maria A Lazzari
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  71     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2002-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-30     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Affiliation:
Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina, Buenos Aires, Argentina. laugennari@hematologia.anm.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Activated Protein C Resistance / blood,  genetics
Antibodies, Antiphospholipid / pharmacology*
Female
Humans
Lupus Coagulation Inhibitor / pharmacology
Male
Phenotype
Predictive Value of Tests
Protein C / drug effects,  metabolism*
Reagent Kits, Diagnostic
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Lupus Coagulation Inhibitor; 0/Protein C; 0/Reagent Kits, Diagnostic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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