Document Detail

Antiphospholipid antibodies impact the protein C (PC) pathway behavior.
MedLine Citation:
PMID:  12353314     Owner:  NLM     Status:  MEDLINE    
Antiphospholipid antibodies may interfere with the PC pathway, displaying a resistance to the activated PC (resistant phenotype). This effect was evaluated by the APCR and the ProCG systems in 36 lupus anticoagulant samples, yielding abnormal results in 47% of APCR(original), 17% of APCR(modified), and 22% of ProCG test. ProCG values correlated with APCR(original) but not with APCR(modified). Most of lupus anticoagulants affecting the PC pathway showed abnormal APCR(original) results but not abnormal ProCG values. The different behavior between both systems may be due to the heterogeneity of the antibodies or could be attributed to the fact that, in the ProCG, a PC activator is added, while the APCR employs already activated exogenous PC.
Laura C Gennari; Alicia N Blanco; María Fabiana Alberto; Silvia H Grosso; Andrea A Peirano; Maria A Lazzari
Related Documents :
6649024 - Stability of plasma fibrinogen during storage of platelet concentrates at 22 degrees c.
22366284 - Prednisolone exerts exquisite inhibitory properties on platelet functions.
8928484 - Evaluation of storage conditions of platelet concentrates prepared from pooled buffy co...
9259824 - Improved in-vitro quality of platelet concentrates stored in a dextrose-free synthetic ...
16406554 - Presence of anti-platelet igm and igg antibodies in dogs naturally infected by leishman...
7872994 - The inhibitory effect of methotrexate on paf-induced neutrophil and eosinophil locomoti...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  71     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2002-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-30     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina, Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Activated Protein C Resistance / blood,  genetics
Antibodies, Antiphospholipid / pharmacology*
Lupus Coagulation Inhibitor / pharmacology
Predictive Value of Tests
Protein C / drug effects,  metabolism*
Reagent Kits, Diagnostic
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Lupus Coagulation Inhibitor; 0/Protein C; 0/Reagent Kits, Diagnostic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tensile destruction test as an estimation of partial proteolysis in fibrin clots.
Next Document:  N-ras and p53 gene mutations in Japanese patients with myeloproliferative disorders.