Document Detail


Antiphospholipid antibodies: discovery, definitions, detection and disease.
MedLine Citation:
PMID:  12689618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiphospholipid antibodies (aPL) are immunoglobulins of IgG, IgM and IgA isotypes that target phospholipid (PL) and/or PL-binding plasma proteins. Detection of aPL in the laboratory is done currently by both immunoassays and functional coagulation tests. Convention defines aPL specificity in immunoassays according to the particular PL substrate present, for example aPS represents antiphosphatidylserine antibodies. This may be technically incorrect inasmuch as a particular PL may be responsible for binding and highly concentrating a specific plasma protein, the latter then becomes the target for the aPL. The binding of beta(2)GP-I (apolipoprotein H) to the negatively charged PL, cardiolipin (CL) provides a good example of this circumstance. In contrast, aPL which specifically prolong coagulation times in in vitro are called lupus anticoagulants (LA). The precise PL target(s) of the aPL responsible for LA activities are unknown and often debated. The persistent finding of aPL in patients in association with abnormal blood clotting and a myriad of neurological, obstetrical and rheumatic disorders often compounded by autoimmune diseases has led to an established clinical diagnosis termed antiphospholipid syndrome (APS). The common denominator for these APS patients is the presence of circulating aPL on two or more occasions and the observation of events attributable to abnormal or accelerated blood clotting somewhere in vivo. The purpose of this review is to collect, collate, and consolidate information concerning aPL.
Authors:
John A McIntyre; Dawn R Wagenknecht; W Page Faulk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in lipid research     Volume:  42     ISSN:  0163-7827     ISO Abbreviation:  Prog. Lipid Res.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900832     Medline TA:  Prog Lipid Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  176-237     Citation Subset:  IM    
Affiliation:
HLA-Vascular Biology Laboratory, St. Francis Hospital and Healthcare Centers, 1600 Albany Street, Beech Grove, IN 46107, USA. john.mcintyre@ssfhs.org
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Anticardiolipin / blood
Antibodies, Antiphospholipid / blood*
Antiphospholipid Syndrome / diagnosis*
Autoantibodies / blood
Graft Rejection / immunology
Humans
Immunoassay / methods
Organ Transplantation
Phosphatidylcholines / immunology
Phosphatidylserines / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Antibodies, Antiphospholipid; 0/Autoantibodies; 0/Phosphatidylcholines; 0/Phosphatidylserines

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