Document Detail


Antiphospholipid antibodies as a possible risk factor for atherosclerosis in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  17015143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis shares many similarities with inflammatory and autoimmune diseases, among them rheumatoid arthritis (RA). Anticardiolipin antibodies (aCL) and antibodies against beta2-glycoprotein I (anti-beta2GPI) have been detected in sera of RA patients in several studies. We demonstrated aCL and anti-beta2GPI in a selected group of 70 patients with RA (premenopausal women, non-diabetic, non-hypertensive) and compared them with age- and sex-matched controls. There was a significant higher internal carotid artery intima-media thickness and number of plaques in RA patients compared to controls. aCL of IgG and IgM classes were present in 15.7% of RA patients as compared to 5% in the control group. Thirty percent of RA patients had anti-beta2GPI of IgG, IgM and IgA classes compared to 7.5% in controls. Major differences were seen in IgG and IgA classes. Our results support the idea that aCL and anti-beta2GPI represent an important risk factor for atherosclerosis in RA patients. Elevated levels of phosphatidylserine-dependent antiprothrombin antibodies did not contribute significantly to the general prevalence of antiphospholipid antibodies.
Authors:
Artur Pahor; Radovan Hojs; Iztok Holc; Ales Ambrozic; Sasa Cucnik; Tanja Kveder; Blaz Rozman
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Publication Detail:
Type:  Journal Article     Date:  2006-06-09
Journal Detail:
Title:  Immunobiology     Volume:  211     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-03     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  689-94     Citation Subset:  IM    
Affiliation:
Teaching Hospital, Maribor, Slovenia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Antiphospholipid / blood*
Arthritis, Rheumatoid / blood*
Atherosclerosis / etiology*
Carotid Arteries / pathology
Carotid Artery Diseases / etiology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Premenopause
Risk Factors
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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