Document Detail

Antiphospholipid Syndrome during pregnancy: the state of the art.
MedLine Citation:
PMID:  22439075     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Obstetric complications are the hallmark of antiphospholipid syndrome. Recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency are the most severe APS-related complication for pregnant women. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. Complement activation might have a central pathogenetic role. These factors, associated with the typical changes in the hemostatic system during normal pregnancy, result in a hypercoagulable state. This is responsible of thrombosis that is presumed to provoke many of the pregnancy complications associated with APS. Obstetric care is based on combined medical-obstetric high-risk management and treatment with the association between aspirin and heparin. This review aims to deter- mine the current state of the art of APS by investigating the knowledge achievements of recent years, to provide the most appropriate diagnostic and therapeutic management for pregnant women suffering from this syndrome.
Fosca A F Di Prima; Oriana Valenti; Entela Hyseni; Elsa Giorgio; Marianna Faraci; Eliana Renda; Roberta De Domenico; Santo Monte
Related Documents :
19876825 - The hidden maternal-fetal interface: events involving the lymphoid organs in maternal-f...
2810235 - Immunopotentiation and pregnancy loss.
1285885 - Remission of rheumatoid arthritis during pregnancy and maternal-fetal class ii alloanti...
22755545 - How do we manage vte in pregnancy? -a retrospective review of the practice of diagnosin...
16728075 - Total ascorbate and dehydroascorbate concentrations in porcine ovarian stroma, follicle...
453065 - Dietary zinc intake of low-income pregnant women of mexican descent.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of prenatal medicine     Volume:  5     ISSN:  1971-3290     ISO Abbreviation:  J Prenat Med     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2012-03-22     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101522906     Medline TA:  J Prenat Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  41-53     Citation Subset:  -    
Policlinico Hospital, Department of Obstetrics and Gynecology, University of Catania, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gestational weight gain, prepregnancy body mass index related to pregnancy outcomes in KAZERUN, FARS...
Next Document:  The use of uterine artery doppler as a predictive tool for adverse gestational outcomes in pregnant ...