| Antiphospholipid Syndrome during pregnancy: the state of the art. | |
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MedLine Citation:
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PMID: 22439075 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Obstetric complications are the hallmark of antiphospholipid syndrome. Recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency are the most severe APS-related complication for pregnant women. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. Complement activation might have a central pathogenetic role. These factors, associated with the typical changes in the hemostatic system during normal pregnancy, result in a hypercoagulable state. This is responsible of thrombosis that is presumed to provoke many of the pregnancy complications associated with APS. Obstetric care is based on combined medical-obstetric high-risk management and treatment with the association between aspirin and heparin. This review aims to deter- mine the current state of the art of APS by investigating the knowledge achievements of recent years, to provide the most appropriate diagnostic and therapeutic management for pregnant women suffering from this syndrome. |
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Authors:
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Fosca A F Di Prima; Oriana Valenti; Entela Hyseni; Elsa Giorgio; Marianna Faraci; Eliana Renda; Roberta De Domenico; Santo Monte |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of prenatal medicine Volume: 5 ISSN: 1971-3290 ISO Abbreviation: J Prenat Med Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2012-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101522906 Medline TA: J Prenat Med Country: Italy |
Other Details:
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Languages: eng Pagination: 41-53 Citation Subset: - |
Affiliation:
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Policlinico Hospital, Department of Obstetrics and Gynecology, University of Catania, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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