Document Detail

Antioxidative and hypocholesterolemic effect of Lactobacillus casei ssp casei (biodefensive properties of lactobacilli).
MedLine Citation:
PMID:  16940685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A positive correlation between an individual's cholesterol level and development of CHD has been suggested. Low levels of high-density lipoprotein cholesterol (HDL-C) and high levels of low-density lipoprotein cholesterol (LDL-C) are important risk factors and oxidation of LDL has been implicated as an initiator of atherosclerosis. AIM: Attempts are being made worldwide for the search of effective antioxidants that can prevent oxidation of LDL. Role of fermented milk and culture containing dairy products as effective antioxidants and their potential hypocholesterolemic effect is the focus of research. Keeping this in view, the various lactobacilli cultures were screened for their in vitro antioxidative activity. Lactobacillus casei ssp casei showing maximum antioxidative activity was selected for carrying out in vivo studies. SETTINGS AND DESIGN: Six groups of Wistar albino rats were fed on diets containing 20% fresh or oxidized soybean oil supplemented with 5% lyophilized culture or fermented milk prepared using L. casei ssp casei for a period of 90 days. The plasma was separated in different lipoprotein fractions and analyzed for cholesterol content and thiobarbituric acid reactive substances (TBARS). RESULTS: The cholesterol levels were less in plasma of groups fed on fermented milk by 2-11% and by 15-25% in groups fed on lyophilized culture as compared to group fed on skim milk. The levels of TBARS were lower in the LDL fraction of plasma in rats fed on fermented milk or culture than the control group fed on skim milk. CONCLUSIONS: The results depict the cholesterol-lowering and antioxidative potential of Lactobacillus casei ssp casei for their application as dietary adjunct.
Suman Kapila; ; P R Sinha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of medical sciences     Volume:  60     ISSN:  0019-5359     ISO Abbreviation:  Indian J Med Sci     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2006-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373023     Medline TA:  Indian J Med Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  361-70     Citation Subset:  IM    
Animal Biochemistry Division, National Dairy Research Institute, Karnal, India.
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MeSH Terms
Antioxidants / pharmacology*
Atherosclerosis / prevention & control*
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Hyperlipidemias / prevention & control*
Lactobacillus casei / chemistry,  metabolism*
Rats, Wistar
Vitamin E
Reg. No./Substance:
0/Antioxidants; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 1406-18-4/Vitamin E

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