| Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. | |
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MedLine Citation:
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PMID: 15809365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In chronic heart failure (CHF), cross-talk between inflammatory activation and oxidative stress has been anticipated in skeletal muscle (SM). The role of the radical scavenger enzymes superoxide dismutase (SOD), catalase (Cat), and glutathione peroxidase (GPX), which remove oxygen radicals, has never been assessed in the SM in this context. Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF. METHODS AND RESULTS: Twenty-three patients with CHF were randomized to either 6 months of exercise training (T) or a sedentary lifestyle (C); 12 age-matched healthy subjects (HS) were studied in parallel. Activity of Cat, SOD, and GPX was assessed in SM biopsies before and after 6 months (6 months). Oxidative stress was determined by measuring nitrotyrosine formation. SOD, Cat, and GPX activity was reduced by 31%, 57%, and 51%, respectively, whereas nitrotyrosine formation was increased by 107% in SM in CHF (P<0.05 versus HS). In CHF, exercise training augmented GPX and Cat activity in SM by 41% (P<0.05 versus before and group C) and 42% (P<0.05 versus before and group C), respectively, and decreased nitrotyrosine production by 35% (from 3.8+/-0.4% tissue area before to 2.5+/-0.3% after 6 months; P<0.05 versus before). CONCLUSIONS: The reduced activity of major antioxidative enzymes in the SM of CHF patients is associated with increased local oxidative stress. Exercise training exerts antioxidative effects in the SM in CHF, in particular, due to an augmentation in activity of radical scavenger enzymes. |
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Authors:
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Axel Linke; Volker Adams; Paul Christian Schulze; Sandra Erbs; Stephan Gielen; Eduard Fiehn; Sven Möbius-Winkler; Andreas Schubert; Gerhard Schuler; Rainer Hambrecht |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2005-04-04 |
Journal Detail:
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Title: Circulation Volume: 111 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-12 Completed Date: 2005-11-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 1763-70 Citation Subset: AIM; IM |
Affiliation:
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Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany. linkea@medizin.uni-leipzig.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Catalase / analysis, genetics Chronic Disease Exercise Therapy* Free Radical Scavengers / analysis Glutathione Peroxidase / analysis, genetics Heart Failure / enzymology, metabolism, therapy* Humans Male Middle Aged Muscle, Skeletal / chemistry, enzymology, metabolism Oxidative Stress* Pulmonary Gas Exchange RNA, Messenger / analysis Superoxide Dismutase / analysis, genetics |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/RNA, Messenger; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
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