| Antioxidative characteristics and inhibition of alpha-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare. | |
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MedLine Citation:
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PMID: 20482617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antioxidant activities of vanillin and vanillic acid isolated from Origanum vulgare are investigated. These compounds may serve as agents for antimelanogenesis. Vanillic acid is a stronger antioxidant than vanillin, in terms of free radical scavenging activity, reducing power and inhibition of lipid peroxidation. The inhibition of cellular reactive oxygen species (ROS) in H(2)O(2)-treated BNLCL2 cells by vanillic acid exceeds that of ascorbic acid (AA) or trolox. In B16F0 cells stimulated with alpha-melanocyte-stimulating hormone (alpha-MSH), vanillic acid reduced cellular tyrosinase activity, DOPA oxidase and melanin contents, as well as down-regulated expressions of melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related proteins 2 (TRP-2) and TRP-1. Vanillin did not express inhibition of tyrosinase activity. These results supported that vanillic acid is a significantly stronger antioxidant than vanillin and exhibited stronger antimelanogenesis performance because of the structural presence of the carboxyl group. |
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Authors:
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Tzung-Han Chou; Hsiou-Yu Ding; Wei Jing Hung; Chia-Hua Liang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental dermatology Volume: 19 ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 742-50 Citation Subset: IM |
Affiliation:
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Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Benzaldehydes / pharmacology* Cell Line Cell Line, Tumor Cell Survival / drug effects Cells, Cultured Fibroblasts / cytology, drug effects, metabolism Lipid Peroxidation / drug effects Liver / cytology, drug effects, metabolism Male Melanins / antagonists & inhibitors, metabolism* Melanoma, Experimental / metabolism, pathology Mice Mice, Inbred ICR Models, Animal Origanum* Plant Extracts / pharmacology* Reactive Oxygen Species / metabolism Thiobarbituric Acid Reactive Substances / metabolism Vanillic Acid / pharmacology* alpha-MSH / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Benzaldehydes; 0/Melanins; 0/Plant Extracts; 0/Reactive Oxygen Species; 0/Thiobarbituric Acid Reactive Substances; 121-33-5/vanillin; 121-34-6/Vanillic Acid; 581-05-5/alpha-MSH |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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