Document Detail

Antioxidative characteristics and inhibition of alpha-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare.
MedLine Citation:
PMID:  20482617     Owner:  NLM     Status:  MEDLINE    
The antioxidant activities of vanillin and vanillic acid isolated from Origanum vulgare are investigated. These compounds may serve as agents for antimelanogenesis. Vanillic acid is a stronger antioxidant than vanillin, in terms of free radical scavenging activity, reducing power and inhibition of lipid peroxidation. The inhibition of cellular reactive oxygen species (ROS) in H(2)O(2)-treated BNLCL2 cells by vanillic acid exceeds that of ascorbic acid (AA) or trolox. In B16F0 cells stimulated with alpha-melanocyte-stimulating hormone (alpha-MSH), vanillic acid reduced cellular tyrosinase activity, DOPA oxidase and melanin contents, as well as down-regulated expressions of melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related proteins 2 (TRP-2) and TRP-1. Vanillin did not express inhibition of tyrosinase activity. These results supported that vanillic acid is a significantly stronger antioxidant than vanillin and exhibited stronger antimelanogenesis performance because of the structural presence of the carboxyl group.
Tzung-Han Chou; Hsiou-Yu Ding; Wei Jing Hung; Chia-Hua Liang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental dermatology     Volume:  19     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  742-50     Citation Subset:  IM    
Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
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MeSH Terms
Antioxidants / pharmacology*
Benzaldehydes / pharmacology*
Cell Line
Cell Line, Tumor
Cell Survival / drug effects
Cells, Cultured
Fibroblasts / cytology,  drug effects,  metabolism
Lipid Peroxidation / drug effects
Liver / cytology,  drug effects,  metabolism
Melanins / antagonists & inhibitors,  metabolism*
Melanoma, Experimental / metabolism,  pathology
Mice, Inbred ICR
Models, Animal
Plant Extracts / pharmacology*
Reactive Oxygen Species / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Vanillic Acid / pharmacology*
alpha-MSH / pharmacology*
Reg. No./Substance:
0/Antioxidants; 0/Benzaldehydes; 0/Melanins; 0/Plant Extracts; 0/Reactive Oxygen Species; 0/Thiobarbituric Acid Reactive Substances; 121-33-5/vanillin; 121-34-6/Vanillic Acid; 581-05-5/alpha-MSH

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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