Document Detail


Antioxidation of human low density lipoprotein by morin hydrate.
MedLine Citation:
PMID:  7596225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at 100 microM concentration, effectively inhibits Cu(2+)-induced oxidation of LDL. The oxidation of LDL was assessed by agarose gel electrophoresis. This was further studied by measuring the increased values of the malondialdehyde equivalents and the decreased numbers of reactive amino groups on oxidized LDL. Trolox, at equimolar concentrations, exhibit similar effects in preventing oxidation of LDL.
Authors:
T W Wu; K P Fung; C C Yang; R D Weisel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  57     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  PL51-6     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / pharmacology*
Chromans / pharmacology
Flavonoids / pharmacology*
Humans
Lipoproteins, LDL / metabolism*
Malondialdehyde / metabolism
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Chromans; 0/Flavonoids; 0/Lipoproteins, LDL; 480-16-0/morin; 542-78-9/Malondialdehyde; 56305-04-5/6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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