Document Detail


Antioxidants: their role in pregnancy and miscarriage.
MedLine Citation:
PMID:  11229372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to examine the role of antioxidants within the normal menstrual cycle, in healthy pregnancy, and in women suffering first-trimester miscarriage. The antioxidants chosen comprised of two from peripheral blood-plasma thiol and ceruloplasmin-and two extracellular parameters-superoxide dismustase (SOD) and red cell lysate thiol. We found that antioxidant levels varied little throughout the menstrual cycle. Pregnancies that went successfully to term were associated with increased levels of ceruloplasmin and SOD early in the first trimester. These changes were thought to offer the cell protection from the damage caused by the increased oxidative stress associated with pregnancy. First-trimester miscarriage was associated with significantly reduced levels of SOD. A subgroup of patients who miscarried in their first pregnancy, but whose second pregnancies were successful, had higher levels of plasma thiol and significantly reduced levels of red cell lysate thiol in the on-going pregnancy compared to levels at the time of miscarriage. Miscarriage and pregnancy appear to be associated with increased oxidative stress. In a successful pregnancy, however, changes occurred within the peripheral blood that offered protection from oxidant attack.
Authors:
C Jenkins; R Wilson; J Roberts; H Miller; J H McKillop; J J Walker
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  2     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2000  
Date Detail:
Created Date:  2001-03-02     Completed Date:  2001-05-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  623-8     Citation Subset:  IM    
Affiliation:
University Department of Medicine, Glasgow Royal Infirmary, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / metabolism*
Adult
Antioxidants / metabolism*
Ceruloplasmin / metabolism
Erythrocytes / metabolism
Female
Gestational Age
Humans
Menstrual Cycle
Oxidative Stress
Pregnancy
Sulfhydryl Compounds / metabolism
Superoxide Dismutase / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Sulfhydryl Compounds; EC 1.15.1.1/Superoxide Dismutase; EC 1.16.3.1/Ceruloplasmin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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