Document Detail


Antioxidants promote establishment of trypanosome infections in tsetse.
MedLine Citation:
PMID:  17306056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Efficient, cyclical transmission of trypanosomes through tsetse flies is central to maintenance of human sleeping sickness and nagana across sub-Saharan Africa. Infection rates in tsetse are normally very low as most parasites ingested with the fly bloodmeal die in the fly gut, displaying the characteristics of apoptotic cells. Here we show that a range of antioxidants (glutathione, cysteine, N-acetyl-cysteine, ascorbic acid and uric acid), when added to the insect bloodmeal, can dramatically inhibit cell death of Trypanosoma brucei brucei in tsetse. Both L- and D-cysteine invoked similar effects suggesting that inhibition of trypanosome death is not dependent on protein synthesis. The present work suggests that antioxidants reduce the midgut environment protecting trypanosomes from cell death induced by reactive oxygen species.
Authors:
E T MacLeod; I Maudlin; A C Darby; S C Welburn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-19
Journal Detail:
Title:  Parasitology     Volume:  134     ISSN:  0031-1820     ISO Abbreviation:  Parasitology     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401121     Medline TA:  Parasitology     Country:  England    
Other Details:
Languages:  eng     Pagination:  827-31     Citation Subset:  IM    
Affiliation:
Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Female
Gastrointestinal Tract / parasitology
Host-Parasite Interactions / drug effects*
Insect Vectors / drug effects*,  parasitology*
Male
Trypanosoma brucei brucei / physiology*
Tsetse Flies / drug effects*,  parasitology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antioxidants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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