Document Detail

Antioxidants promote establishment of trypanosome infections in tsetse.
MedLine Citation:
PMID:  17306056     Owner:  NLM     Status:  MEDLINE    
Efficient, cyclical transmission of trypanosomes through tsetse flies is central to maintenance of human sleeping sickness and nagana across sub-Saharan Africa. Infection rates in tsetse are normally very low as most parasites ingested with the fly bloodmeal die in the fly gut, displaying the characteristics of apoptotic cells. Here we show that a range of antioxidants (glutathione, cysteine, N-acetyl-cysteine, ascorbic acid and uric acid), when added to the insect bloodmeal, can dramatically inhibit cell death of Trypanosoma brucei brucei in tsetse. Both L- and D-cysteine invoked similar effects suggesting that inhibition of trypanosome death is not dependent on protein synthesis. The present work suggests that antioxidants reduce the midgut environment protecting trypanosomes from cell death induced by reactive oxygen species.
E T MacLeod; I Maudlin; A C Darby; S C Welburn
Related Documents :
19207606 - Urates in uric acid renal calculi.
18834626 - Association of three genetic loci with uric acid concentration and risk of gout: a geno...
7783706 - Uric acid nephrolithiasis.
6348486 - Effect of natural oestrogen/gestagen therapy on uric acid metabolism in post-menopausal...
10552136 - The herbicidally active compound n-2-(6-methyl-pyridyl)-aminomethylene bisphosphonic ac...
18494016 - Determination of amino acids by capillary electrophoresis-electrospray ionization-mass ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-19
Journal Detail:
Title:  Parasitology     Volume:  134     ISSN:  0031-1820     ISO Abbreviation:  Parasitology     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401121     Medline TA:  Parasitology     Country:  England    
Other Details:
Languages:  eng     Pagination:  827-31     Citation Subset:  IM    
Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / pharmacology*
Gastrointestinal Tract / parasitology
Host-Parasite Interactions / drug effects*
Insect Vectors / drug effects*,  parasitology*
Trypanosoma brucei brucei / physiology*
Tsetse Flies / drug effects*,  parasitology*
Grant Support
//Wellcome Trust
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Age-dependent dynamics of Theileria equi and Babesia caballi infections in southwest Mongolia based ...
Next Document:  In vitro efficacy of nitro- and bromo-thiazolyl-salicylamide compounds (thiazolides) against Besnoit...