Document Detail

Antioxidants increase the ventilatory response to hyperoxic hypercapnia.
MedLine Citation:
PMID:  16959916     Owner:  NLM     Status:  MEDLINE    
RATIONALE: The mechanisms by which chemoreceptors process carbon dioxide stimuli are poorly understood. Recent in vitro studies suggest a role of reactive oxygen species in central carbon dioxide chemoreception. OBJECTIVES: We tested the hypothesis that antioxidant treatment modulates the ventilatory response to carbon dioxide in healthy humans, either during unloaded breathing or after strenuous resistive breathing. METHODS: In the first experiment of this randomized, double-blind, placebo-controlled study, 14 healthy males completed hyperoxic carbon dioxide rebreathing, received either antioxidants (vitamins E, A, and C for 2 mo, allopurinol for 15 d, and N-acetylcysteine for 3 d) (n = 7) or placebo (n = 7), and repeated rebreathing 3 mo later. In the second experiment, 18 healthy males completed a series of rebreathing tests before and after strenuous resistive breathing. Subjects repeated the same protocol 3 mo later, after they had received antioxidants (n = 9) or placebo (n = 9). MAIN RESULTS: After antioxidants, the sensitivity of the ventilatory (minute ventilation) response to carbon dioxide increased (mean [+/- SEM], 3.2 +/- 0.5 vs. 1.7 +/- 0.4 L/min/mm Hg; p < 0.001). Antioxidants also increased the sensitivity to carbon dioxide before and at 5, 30, and 120 min after resistive breathing (p = 0.01). This effect was entirely due to increased tidal volume. Antioxidants did not influence the breathing pattern during resting breathing or the rapid shallow breathing response to carbon dioxide at 5 min after resistive breathing. CONCLUSIONS: Antioxidants, by augmenting the tidal volume, increase the sensitivity of the ventilatory response to carbon dioxide, either during unloaded breathing or after resistive breathing.
Spyros Zakynthinos; Paraskevi Katsaounou; Maria-Helena Karatza; Charis Roussos; Theodoros Vassilakopoulos
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-09-07
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  175     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  AIM; IM    
Medical School of Athens University, Department of Critical Care and Pulmonary Services, Evangelismos Hospital, 45-47 Ipsilandou St., GR 106 75 Athens, Greece.
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MeSH Terms
Antioxidants / pharmacology*
Carbon Dioxide / agonists*,  pharmacology
Hypercapnia / chemically induced,  physiopathology*
Oxidative Stress* / drug effects
Pulmonary Ventilation / drug effects*
Respiration / drug effects
Tidal Volume / drug effects
Reg. No./Substance:
0/Antioxidants; 0/Placebos; 124-38-9/Carbon Dioxide

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