Document Detail


Antioxidants for hypertension.
MedLine Citation:
PMID:  9818200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increasing evidence implicates reactive oxygen species in the pathogenesis of hypertension and its cardiovascular complications. By altering the balance in the endothelium between vasoconstrictors such as thromboxane and isoprostanes and vasodilators such as nitric oxide, reactive oxygen species contribute to endothelium-dependent contractions and increased vascular resistance. Antioxidants can restore endothelial function and decrease blood pressure in several models of hypertension and in some, but not all, studies of humans with essential hypertension. The potential of antioxidant therapy for hypertension is considerable.
Authors:
C Kitiyakara; C S Wilcox
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  7     ISSN:  1062-4821     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-14     Completed Date:  1999-01-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
Affiliation:
Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA. kitiyakc@medlib.georgetown.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / therapeutic use*
Humans
Hypertension / drug therapy*,  metabolism,  pathology
Reactive Oxygen Species / metabolism*
Grant Support
ID/Acronym/Agency:
DK36079/DK/NIDDK NIH HHS; DK49870/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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