Document Detail


Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans.
MedLine Citation:
PMID:  12633732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethanol is the most common human teratogen, and heavy drinking during pregnancy can result in serious adverse outcomes to the fetus. The cellular mechanisms by which ethanol induces damage in utero are not well understood, while induction of oxidative stress is believed to be one putative mechanism. Our objective is to review the data of antioxidant effects in experimental models of fetal alcohol syndrome. Prior to the description of the available experimental data, we will briefly review the mechanisms leading to ethanol-induced oxidative stress. Ethanol-induced oxidative damage to the fetus could be attenuated by a variety of antioxidants as was documented in whole animal and tissue culture studies. Experiments, retrieved from the literature search, are described and criticized. Although experimental data are still limited, the application of a treatment strategy that includes antioxidants is justified since antioxidant treatment in human pregnancy for pre-eclampsia was demonstrated to be safe and effective. The available experimental evidence and the safety of vitamins C and E in pregnancy suggest that experimental use of antioxidants in alcohol-consuming mothers should be seriously considered to reduce fetal alcohol damage.
Authors:
Raanan Cohen-Kerem; Gideon Koren
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  25     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-03-13     Completed Date:  2003-05-30     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Toronto, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. raanan.cohen-kerem@sickkids.ca
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MeSH Terms
Descriptor/Qualifier:
Alcohol-Induced Disorders, Nervous System / drug therapy*,  physiopathology,  prevention & control*
Antioxidants / pharmacology,  therapeutic use*
Ascorbic Acid / pharmacology,  therapeutic use
Central Nervous System / drug effects,  metabolism,  physiopathology
Ethanol / antagonists & inhibitors*,  toxicity
Female
Fetal Alcohol Syndrome / drug therapy*,  physiopathology,  prevention & control*
Fetus / drug effects*,  pathology,  physiopathology
Humans
Oxidative Stress / drug effects,  physiology
Pregnancy
Vitamin E / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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