| Antioxidants and exercise. | |
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MedLine Citation:
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PMID: 10410839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muscular exercise results in an increased production of radicals and other forms of reactive oxygen species. Further more, growing evidence implicates cytotoxic ROS as an underlying cause in exercise-induced disturbances in muscle redox status that could result in muscle fatigue or injury. Muscle cells contain complex cellular defense mechanisms to minimize the risk for oxidative injury. Two major classes of endogenous protective mechanisms work together to reduce the harmful effects of oxidants in the cell: (1) enzymatic and (2) nonenzymatic antioxidants. Key antioxidant enzymes include superoxide dismutase, glutathione peroxidase, and catalase. These enzymes are responsible for removing superoxide radicals, hydrogen peroxide or organic hydroperoxides, and hydrogen peroxide, respectively. Important nonenzymatic antioxidants include vitamins E and C, beta-carotene, GSH, uric acid, ubiquinone, and bilirubin. Vitamin E, beta-carotene, and ubiquinone are located in lipid regions of the cell, whereas uric acid, GSH, and bilirubin are in aqueous compartments of the cell. Although numerous animal experiments have demonstrated that the addition of antioxidants can improve muscular performance, to date, limited evidence shows that dietary supplementation with antioxidants improves human performance. This is an important area for future research. |
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Authors:
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S K Powers; K Hamilton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinics in sports medicine Volume: 18 ISSN: 0278-5919 ISO Abbreviation: Clin Sports Med Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-17 Completed Date: 1999-09-17 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8112473 Medline TA: Clin Sports Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 525-36 Citation Subset: IM; S |
Affiliation:
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Department of Exercise and Sport Sciences, University of Florida, Gainesville, USA. spowers@hhp.ufl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism* Enzymes / metabolism, physiology Exercise / physiology* Humans Muscle, Skeletal / metabolism Oxidoreductases / metabolism, physiology Sports / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Enzymes; EC 1.-/Oxidoreductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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