Document Detail


Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery.
MedLine Citation:
PMID:  19657294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study aimed to determine the effects of 4 wk of antioxidants (AOX) supplementation on exercise-induced lipid peroxidation, muscle damage, and inflammation in kayakers. METHODS: Subjects (n = 20) were randomly assigned to receive a placebo (PLA) or an AOX capsule (AOX; 272 mg of alpha-tocopherol, 400 mg of vitamin C, 30 mg of beta-carotene, 2 mg of lutein, 400 mug of selenium, 30 mg of zinc, and 600 mg of magnesium). Blood samples were collected at rest and 15 min after a 1000-m kayak race, both before and after the supplementation period, for analysis of alpha-tocopherol, alpha-carotene, beta-carotene, lycopene, lutein plus zeaxanthin, vitamin C, uric acid, total AOX status (TAS), thiobarbituric reactive acid substances (TBARS) and interleukin-6 (IL-6) levels, and creatine kinase (CK), superoxide dismutase (SOD), glutathione reductase (Gr), and glutathione peroxidase (GPx) activities. RESULTS: With supplementation, plasma alpha-tocopherol (P = 0.003) and beta-carotene (P = 0.007) augmented significantly in the AOX group. IL-6 (exercise, P = 0.039), TBARS (exercise, P < 0.001), and uric acid (exercise, P = 0.032) increased significantly in response to the exercise regardless of treatment group. Cortisol level raised more from pre- to postsupplementation period in the PLA group (time x supplementation, P = 0.002). Although TAS declined after exercise before intervention, it increased above preexercise values after the 4-wk period in the AOX group (supplementation x time x exercise, P = 0.034). CK increased after exercise in both groups (exercise effect, P < 0.001) and decreased from week 0 to week 4 more markedly in the PLA group (supplementation x time, P = 0.049). CONCLUSIONS: AOX supplementation does not offer protection against exercise-induced lipid peroxidation and inflammation and may hinder the recovery of muscle damage.
Authors:
Vitor H Teixeira; Hugo F Valente; Susana I Casal; A Franklim Marques; Pedro A Moreira
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  41     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1752-60     Citation Subset:  IM; S    
Affiliation:
Faculty of Nutrition and Food Sciences, University of Porto, Porto, Potugal. vhugoteixeira@fcna.up.pt
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antioxidants / administration & dosage,  metabolism*
Double-Blind Method
Exercise / physiology
Female
Humans
Lipid Peroxidation / drug effects*
Male
Muscle, Skeletal / drug effects*,  injuries
Oxidative Stress / drug effects
Portugal
Young Adult
Chemical
Reg. No./Substance:
0/Antioxidants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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