| Antioxidants and cataract: (cataract induction in space environment and application to terrestrial aging cataract). | |
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MedLine Citation:
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PMID: 9305537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of several antioxidants and cysteine-elevating precursor drugs (prodrugs) was tested on lens damage occurring after in vitro exposure to low levels of 60Co-gamma-irradiation, to simulate in vitro the exposure to radiation in vivo of (1) astronauts (2) jet crews (3) military radiation accident personnel. Tocopherol (100 microM), ascorbic acid (1 mM), R-alpha-lipoic acid (1 mM), and taurine (0.5 mM) protected against radiation-associated protein leakage. MTCA and ribocysteine protected lenses against opacification, LDH and protein leakage, indicating that antioxidants and prodrugs of cysteine appear to offer protection against lens damage caused by low level radiation. |
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Authors:
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V Bantseev; R Bhardwaj; W Rathbun; H Nagasawa; J R Trevithick |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry and molecular biology international Volume: 42 ISSN: 1039-9712 ISO Abbreviation: Biochem. Mol. Biol. Int. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-11-03 Completed Date: 1997-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306673 Medline TA: Biochem Mol Biol Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 1189-97 Citation Subset: IM; S |
Affiliation:
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Department of Biochemistry, University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Ascorbic Acid / pharmacology Carbolines / pharmacology Cataract / physiopathology*, radiotherapy Cysteine / analogs & derivatives, pharmacology Dose-Response Relationship, Radiation L-Lactate Dehydrogenase / drug effects, metabolism, radiation effects Lens, Crystalline / drug effects*, radiation effects* Occupational Diseases Radiation-Protective Agents / pharmacology* Rats Ribose / analogs & derivatives, pharmacology Taurine / pharmacology Thioctic Acid / pharmacology Vitamin E / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Carbolines; 0/Radiation-Protective Agents; 107-35-7/Taurine; 1406-18-4/Vitamin E; 50-69-1/Ribose; 50-81-7/Ascorbic Acid; 52-90-4/Cysteine; 5470-37-1/1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid; 62-46-4/Thioctic Acid; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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