Document Detail


Antioxidants as agents potentiating the antiinflammatory action of indomethacin.
MedLine Citation:
PMID:  1022139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nordihydroguaiaretic acid inhibits prostaglandin (PG) biosynthesis in vitro (ID50=228 muM), with a slope of dose-response curve high (b=209) as compared with indomethacin (ID50=0.1 muM, b=72.1). Butylated hydroxyanisole, in contrast to inactive butylated hydroxytoluene, inhibits PG biosynthesis (ID50=107 muM, b=63). Only norihydroguaiaretic acid (100 mug, s.p.) inhibited the postcarrageenin edema of rat paw. Butylated hydroxyanisole (10 mug, s.p.) given together with a subthreshold (1 mug) dose of indomethacin inhibited the paw edema by 35%, while butylated hydroxytoluene and nordihydroguaiaretic acid produced a similar effect only when given at 10-fold higher doses. The results suggest the possibility of potentiation and prolongation of the anti-inflammatory effect of indomethacin by its simultaneous administration with an antioxidant, butylated hydroxyanisole.
Authors:
H Sobański; J Krupińska; B Cebo; J Mazur; A Kieć-Dembińska
Related Documents :
18292449 - The interaction between inhibitors of nitric oxide synthase and cyclooxygenase in forma...
6585849 - Serum prostaglandin precursors after vaginal examination and amniotomy.
6774739 - Effect of 4'-chloro-5-methoxy-3-biphenylylacetic acid (dka-9) on prostaglandin synthetase.
7649449 - Involvement of prostaglandin e2 synthesis in the intestinal secretory action of escheri...
10401729 - Nicotinic acid and pyridoxine modulate arachidonic acid metabolism in vitro and ex vivo...
6438089 - Biosynthesis and metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid by human ...
17916919 - Accuracy of pedometer steps and time for youth with disabilities.
22071839 - Omega-3 fatty acids supplementation for autism spectrum disorders (asd).
5544299 - Effect of fatty acid derivatives on rumen methane and propionate in vitro.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biologica et medica Germanica     Volume:  35     ISSN:  0001-5318     ISO Abbreviation:  Acta Biol. Med. Ger.     Publication Date:  1976  
Date Detail:
Created Date:  1977-05-12     Completed Date:  1977-05-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370276     Medline TA:  Acta Biol Med Ger     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  1547-51     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents*
Antioxidants / pharmacology*,  therapeutic use
Cattle
Drug Synergism
Edema / drug therapy
Indomethacin / pharmacology*,  therapeutic use
Male
Prostaglandin Antagonists
Rats
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Prostaglandin Antagonists; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Serum glycoproteins level and urinary glycosaminoglycans excretion in drug induced collagen-like syn...
Next Document:  Studies on the specificity of an antiserum against denaturated DNA from Sarcina maxima