Document Detail

Antioxidants as agents potentiating the antiinflammatory action of indomethacin.
MedLine Citation:
PMID:  1022139     Owner:  NLM     Status:  MEDLINE    
Nordihydroguaiaretic acid inhibits prostaglandin (PG) biosynthesis in vitro (ID50=228 muM), with a slope of dose-response curve high (b=209) as compared with indomethacin (ID50=0.1 muM, b=72.1). Butylated hydroxyanisole, in contrast to inactive butylated hydroxytoluene, inhibits PG biosynthesis (ID50=107 muM, b=63). Only norihydroguaiaretic acid (100 mug, s.p.) inhibited the postcarrageenin edema of rat paw. Butylated hydroxyanisole (10 mug, s.p.) given together with a subthreshold (1 mug) dose of indomethacin inhibited the paw edema by 35%, while butylated hydroxytoluene and nordihydroguaiaretic acid produced a similar effect only when given at 10-fold higher doses. The results suggest the possibility of potentiation and prolongation of the anti-inflammatory effect of indomethacin by its simultaneous administration with an antioxidant, butylated hydroxyanisole.
H Sobański; J Krupińska; B Cebo; J Mazur; A Kieć-Dembińska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biologica et medica Germanica     Volume:  35     ISSN:  0001-5318     ISO Abbreviation:  Acta Biol. Med. Ger.     Publication Date:  1976  
Date Detail:
Created Date:  1977-05-12     Completed Date:  1977-05-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370276     Medline TA:  Acta Biol Med Ger     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  1547-51     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents*
Antioxidants / pharmacology*,  therapeutic use
Drug Synergism
Edema / drug therapy
Indomethacin / pharmacology*,  therapeutic use
Prostaglandin Antagonists
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Prostaglandin Antagonists; 53-86-1/Indomethacin

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