| Antioxidants, trace elements and metabolic syndrome in elderly subjects. | |
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MedLine Citation:
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PMID: 21125208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether concentrations of several trace elements and activities of several antioxidant enzymes are modified in metabolic syndrome, and to evaluate their possible association with metabolic syndrome components. Additionally, concentration of CRP, as a marker of inflammation, was measured. DESIGN: Cross-sectional study. PARTICIPANTS: The study group consisted of 100 subjects, aged 71-88 years. MEASUREMENTS: Anthropometric measurements and biochemical analyses of fasting blood samples were performed by standardized methods. According to the International Diabetic Federation (IDF) criteria, metabolic syndrome was diagnosed in 64 subjects. Whole blood glutathione peroxidase (GPx), erythrocyte superoxide dismutase (SOD) and catalase (CAT), serum selenium (SSe), copper (SCu) and zinc (SZn), glucose, lipoprotein profile and C-reactive protein (CRP) were determined in all subjects. RESULTS: No clear influence of metabolic syndrome on SSe, SZn and SCu concentration and SOD and CAT activity was found. However, significantly higher GPx was found in subjects with metabolic syndrome than in subjects without metabolic syndrome (p=0.029), as well as in subjects with hypertriglyceridemia than in control subjects (p=0.038). After adjusting for potentially confounding variables by multiple regression, significant positive relationship between SCu and CRP was found, indicating that elevated levels of Cu could have influence on inflammatory mechanisms. CONCLUSION: Our results suggest that GPx and CRP, as biomarkers of oxidative stress and chronic inflammation, respectively, have significant role in the pathogenesis of metabolic syndrome. |
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Authors:
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A Pizent; M Pavlovic; J Jurasovic; S Dodig; D Pasalic; R Mujagic |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of nutrition, health & aging Volume: 14 ISSN: 1760-4788 ISO Abbreviation: J Nutr Health Aging Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-02 Completed Date: 2011-02-14 Revised Date: 2011-06-15 |
Medline Journal Info:
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Nlm Unique ID: 100893366 Medline TA: J Nutr Health Aging Country: France |
Other Details:
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Languages: eng Pagination: 866-71 Citation Subset: IM |
Affiliation:
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Institute for Medical Research and Occupational Health, Zagreb, Croatia. apizent@imi.hr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / blood Body Mass Index C-Reactive Protein / metabolism Copper / blood Croatia / epidemiology Cross-Sectional Studies Erythrocytes / enzymology Female Glutathione Peroxidase / blood Humans Hypertriglyceridemia / blood, enzymology, physiopathology Inflammation / blood, physiopathology Male Metabolic Syndrome X / blood*, enzymology, epidemiology* Oxidative Stress Oxidoreductases / blood* Rural Health Trace Elements / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Trace Elements; 7440-50-8/Copper; 9007-41-4/C-Reactive Protein; EC 1.-/Oxidoreductases; EC 1.11.1.9/Glutathione Peroxidase |
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