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Antioxidant vitamins in the prevention of atrial fibrillation: what is the evidence?
MedLine Citation:
PMID:  21876823     Owner:  NLM     Status:  In-Data-Review    
Atrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with significant side effects. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. Recently, increasing evidence implicates oxidative stress and inflammation in the pathogenesis of AF. We searched the literature for evidence to support the use of antioxidant vitamins C and E in the prevention of AF. These vitamins, through their reactive-oxygen-species- (ROS-) scavenging effect, have shown a role in AF prevention in both animal and small clinical studies. The available evidence, however, is currently insufficient to support recommendations for their use in the wider patient population. Larger-scale clinical studies are required to confirm these preliminary results. Research is also required to further the understanding of the processes involved in the pathogenesis of AF and the role of antioxidant therapies to prevent the arrhythmia.
Sonia Rasoli; Nicholaos Kakouros; Leanne Harling; Philemon Gukop; Manish Soni; Thanos Athanasiou; Antonios Kourliouros
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Publication Detail:
Type:  Journal Article     Date:  2011-08-23
Journal Detail:
Title:  Cardiology research and practice     Volume:  2011     ISSN:  2090-0597     ISO Abbreviation:  Cardiol Res Pract     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101516542     Medline TA:  Cardiol Res Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164078     Citation Subset:  -    
Department of Cardiothoracic Surgery, St George's Hospital, London SW17 0QT, UK.
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