| Antioxidant supplementation lowers circulating IGF-1 but not F(2)-isoprostanes immediately following anterior cruciate ligament surgery. | |
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MedLine Citation:
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PMID: 19843377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin (IL)-10 is an anti-inflammatory cytokine that suppresses pro-inflammatory cytokines. We previously demonstrated that supplementation with vitamins E and C ameliorated the increase in IL-10 immediately following anterior cruciate ligament (ACL) surgery in the absence of other cytokine perturbations. Since both oxidative stress and insulin-like growth factor-1 (IGF-1) can modulate IL-10 concentrations, the mechanisms for these changes warranted further investigation. Our objective was to evaluate the mechanism for the IL-10 decrease following ACL surgery. This study consisted of randomized, double-blind, placebo-controlled experimental design. Subjects were randomly assigned to daily supplementation with either: (i) antioxidants (AO; vitamins E [alpha-tocopherol] and C [ascorbic acid]; n = 10); or (ii) matching placebos (PL; n = 10). Supplementation started approximately 2 weeks prior to surgery (baseline) and concluded 3 months after surgery. Subjects provided six fasting blood samples at: (i) baseline; (ii) immediately pre-surgery (Pre); (iii) 90 min; (iv) 72 h; (v) 7 days; and (vi) 3 months post-surgery. alpha-Tocopherol, ascorbic acid, F(2)-isoprostane and IGF-1 concentrations were measured in each blood sample. At 90 min relative to other times, plasma F(2)-isoprostane concentrations were significantly (P < 0.05) elevated in both groups, while at 90 min IGF-1 was significantly (P < 0.05) lower in the AO compared to the PL group. The changes in IGF-1 at 90 min relative to baseline were correlated (P < 0.0001) with the changes in IL-10. The decrease in IL-10 observed in the AO group is likely dependent on the decrease IGF-1 since lipid peroxidation was unchanged between the two groups. |
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Authors:
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Tyler Barker; Scott W Leonard; Roy H Trawick; James A Walker; Maret G Traber |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Redox report : communications in free radical research Volume: 14 ISSN: 1743-2928 ISO Abbreviation: Redox Rep. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-21 Completed Date: 2010-01-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9511366 Medline TA: Redox Rep Country: England |
Other Details:
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Languages: eng Pagination: 221-6 Citation Subset: IM |
Affiliation:
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Sport Science Department, The Orthopedic Specialty Hospital, Murray, Utah, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anterior Cruciate Ligament
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surgery* Antioxidants / metabolism*, therapeutic use* Ascorbic Acid / blood*, therapeutic use* Dietary Supplements Double-Blind Method F2-Isoprostanes / blood Humans Insulin-Like Growth Factor I / metabolism Vitamin E / blood*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/F2-Isoprostanes; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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