Document Detail


Antioxidant stobadine and neurobehavioural development of the rat offspring.
MedLine Citation:
PMID:  10703718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stobadine (STO) is a potential neuro- and cardioprotective drug with high antioxidative properties. The presented study investigated the effects of oral STO administration (5, 15 and 50 mg/kg/d) during pregnancy and lactation to dams on neurobehavioural development of their offspring (body growth and maturation, sensory functions, neuromotor and reflex development, levels of activity and emotional reactivity, memory and learning processes). The results of our experiments showed that long-term administration of STO had no adverse effects on the course of pregnancy and lactation in dams and on the neurobehavioural development of offspring.
Authors:
M Dubovický; E Ujházy; P Kovacovský; I Rychlík; J Navarová; J Jansák
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General physiology and biophysics     Volume:  18 Spec No     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  SLOVAKIA    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Affiliation:
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava. exfadubm@savba.savba.sk
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Administration, Oral
Aging / drug effects,  physiology*
Animals
Antioxidants / administration & dosage,  pharmacology*
Carbolines / administration & dosage,  pharmacology*
Female
Lactation
Learning / drug effects*
Litter Size / drug effects
Male
Maze Learning / drug effects
Memory / drug effects
Motor Activity / drug effects*
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Rats, Wistar
Reflex / drug effects*
Startle Reaction / drug effects
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Carbolines; 17411-19-7/dicarbine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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