Document Detail

Antioxidant stobadine and neurobehavioural development of the rat offspring.
MedLine Citation:
PMID:  10703718     Owner:  NLM     Status:  MEDLINE    
Stobadine (STO) is a potential neuro- and cardioprotective drug with high antioxidative properties. The presented study investigated the effects of oral STO administration (5, 15 and 50 mg/kg/d) during pregnancy and lactation to dams on neurobehavioural development of their offspring (body growth and maturation, sensory functions, neuromotor and reflex development, levels of activity and emotional reactivity, memory and learning processes). The results of our experiments showed that long-term administration of STO had no adverse effects on the course of pregnancy and lactation in dams and on the neurobehavioural development of offspring.
M Dubovický; E Ujházy; P Kovacovský; I Rychlík; J Navarová; J Jansák
Related Documents :
19879338 - Mother is not like mother: concurrent pregnancy reduces lactating guinea pigs' responsi...
25246928 - Efficacy of the local endometrial injury in patients who had previous failed ivf-icsi o...
1562518 - Calciotropic hormones during reproduction.
22781078 - Long-acting reversible contraception for adolescents.
22851678 - Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy.
20537328 - Dating gestational age by last menstrual period, symphysis-fundal height, and ultrasoun...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General physiology and biophysics     Volume:  18 Spec No     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  SLOVAKIA    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acoustic Stimulation
Administration, Oral
Aging / drug effects,  physiology*
Antioxidants / administration & dosage,  pharmacology*
Carbolines / administration & dosage,  pharmacology*
Learning / drug effects*
Litter Size / drug effects
Maze Learning / drug effects
Memory / drug effects
Motor Activity / drug effects*
Prenatal Exposure Delayed Effects*
Rats, Wistar
Reflex / drug effects*
Startle Reaction / drug effects
Reg. No./Substance:
0/Antioxidants; 0/Carbolines; 17411-19-7/dicarbine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The role of mitochondria in apoptosis induced in vitro.
Next Document:  Ecotoxicology of metals related to freshwater benthos.