Document Detail

Antioxidant status in newborns and infants suffering from congenital heart defects.
MedLine Citation:
PMID:  14969161     Owner:  NLM     Status:  MEDLINE    
There is a common view that free radicals may play an important role in tissue damage resulting from circulatory insufficiency, cardiosurgery etc. There are very few data concerning the involvement of free radical reactions in the newborns and infants suffering from congenital heart defects (CHD). Antioxidant status was evaluated in 41 newborns and infants under 1 year of age, among them 23 suffering from CHD (14 with left-to-right shunt and 9 with cyanotic heart defect) and 18 healthy controls. The study based on the assessment of activities of antioxidant enzymes in blood (superoxide dismutase, catalase and glutathione peroxidase), levels of low molecular weight antioxidants (vitamin E, uric acid and selenium) and the concentration of malondialdehyde (MDA) as a marker of lipid peroxidation. All subjects had low blood selenium concentration as compared to the level considered as being adequate. Infants suffering from CHD had lower, as compared to healthy controls, plasma vitamin E concentration. The difference was significant in the case of acyanotic ones. The activities of superoxide dismutase and catalase in infants with CHD were not significantly different from the respective values recorded in healthy controls. The activity of glutathione peroxidase in whole blood was the lowest in infants with cyanotic heart defect in whom lipid peroxidation, as evaluated by MDA level, was the most enhanced. Significantly higher plasma concentration of uric acid which may be interpreted as a positive mechanism enabling better protection of red blood cells from peroxidative damage was found in this group of infants. It is concluded that enhanced oxidative stress due to imbalance between prooxidant and antioxidant reactions appears to be associated with congenital heart defect pathology in infants.
Władysław Rokicki; Adam Strzałkowski; Barbara Kłapcińska; Alojzy Danch; Andrzej Sobczak
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wiadomości lekarskie (Warsaw, Poland : 1960)     Volume:  56     ISSN:  0043-5147     ISO Abbreviation:  Wiad. Lek.     Publication Date:  2003  
Date Detail:
Created Date:  2004-02-18     Completed Date:  2004-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9705467     Medline TA:  Wiad Lek     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  IM    
Department of Pediatric Cardiology Medical University of Silesia, Katowice.
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MeSH Terms
Analysis of Variance
Antioxidants / metabolism*
Biological Markers / blood
Case-Control Studies
Catalase / blood
Glutathione Peroxidase / blood
Heart Defects, Congenital / blood*,  enzymology
Infant, Newborn
Malondialdehyde / blood
Oxidative Stress*
Predictive Value of Tests
Risk Factors
Selenium / blood
Superoxide Dismutase / blood
Time Factors
Uric Acid / blood
Vitamin E / blood
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 1406-18-4/Vitamin E; 542-78-9/Malondialdehyde; 69-93-2/Uric Acid; 7782-49-2/Selenium; EC; EC Peroxidase; EC Dismutase

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