| Antioxidant status in newborns and infants suffering from congenital heart defects. | |
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MedLine Citation:
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PMID: 14969161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is a common view that free radicals may play an important role in tissue damage resulting from circulatory insufficiency, cardiosurgery etc. There are very few data concerning the involvement of free radical reactions in the newborns and infants suffering from congenital heart defects (CHD). Antioxidant status was evaluated in 41 newborns and infants under 1 year of age, among them 23 suffering from CHD (14 with left-to-right shunt and 9 with cyanotic heart defect) and 18 healthy controls. The study based on the assessment of activities of antioxidant enzymes in blood (superoxide dismutase, catalase and glutathione peroxidase), levels of low molecular weight antioxidants (vitamin E, uric acid and selenium) and the concentration of malondialdehyde (MDA) as a marker of lipid peroxidation. All subjects had low blood selenium concentration as compared to the level considered as being adequate. Infants suffering from CHD had lower, as compared to healthy controls, plasma vitamin E concentration. The difference was significant in the case of acyanotic ones. The activities of superoxide dismutase and catalase in infants with CHD were not significantly different from the respective values recorded in healthy controls. The activity of glutathione peroxidase in whole blood was the lowest in infants with cyanotic heart defect in whom lipid peroxidation, as evaluated by MDA level, was the most enhanced. Significantly higher plasma concentration of uric acid which may be interpreted as a positive mechanism enabling better protection of red blood cells from peroxidative damage was found in this group of infants. It is concluded that enhanced oxidative stress due to imbalance between prooxidant and antioxidant reactions appears to be associated with congenital heart defect pathology in infants. |
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Authors:
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Władysław Rokicki; Adam Strzałkowski; Barbara Kłapcińska; Alojzy Danch; Andrzej Sobczak |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Wiadomości lekarskie (Warsaw, Poland : 1960) Volume: 56 ISSN: 0043-5147 ISO Abbreviation: Wiad. Lek. Publication Date: 2003 |
Date Detail:
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Created Date: 2004-02-18 Completed Date: 2004-04-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9705467 Medline TA: Wiad Lek Country: Poland |
Other Details:
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Languages: eng Pagination: 337-40 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology Medical University of Silesia, Katowice. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antioxidants / metabolism* Biological Markers / blood Case-Control Studies Catalase / blood Female Glutathione Peroxidase / blood Heart Defects, Congenital / blood*, enzymology Humans Infant Infant, Newborn Male Malondialdehyde / blood Oxidative Stress* Predictive Value of Tests Risk Factors Selenium / blood Superoxide Dismutase / blood Time Factors Uric Acid / blood Vitamin E / blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 1406-18-4/Vitamin E; 542-78-9/Malondialdehyde; 69-93-2/Uric Acid; 7782-49-2/Selenium; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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