| Antioxidant status in the liver of hypertensive and metallothionein-deficient mice. | |
| | |
MedLine Citation:
|
PMID: 14608409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Because oxidative stress is involved in arterial hypertension, impairment of hepatic antioxidant defences could develop in the course of this disease. Metallothionein (MT), an antioxidant protein, is present in high rates in the liver. The aim of this study was to investigate the effect of a mineralocorticoid-salt treatment on blood pressure, hepatic antioxidant enzyme activities, and cardiac MT levels in transgenic MT null mice compared with control mice to further clarify the role of MT during the experimental development of arterial hypertension. Control and transgenic MT -/- mice were submitted to an 8-week mineralocorticoid-salt treatment. Hepatic glutathione peroxidase, glutathione reductase, superoxide dismutase, and catalase activities and cardiac MT and mineral levels were measured. Mineralocorticoid-salt treatment induced an increase in blood pressure in both transgenic MT -/- and control mice that was associated with an impairment of liver antioxidant status. MT deficiency was associated with modifications of hepatic antioxidant enzyme activities and with a decrease in cardiac iron levels. Adaptive processes of antioxidant systems may explain the absence of an effect of metallothionein deficiency on the development of mineralocorticoid-salt hypertension. The interactions that occur between the in vivo antioxidant systems probably produce a complex regulation of the oxidative balance and consequently prevent antioxidant deficiency. |
| | |
Authors:
|
Sylvie Bobillier-Chaumont; Laurence Nicod; Lysiane Richert; Alain Berthelot |
Related Documents
:
|
18573249 - Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in ra... 16705229 - Influence of nebivolol on endothelial dysfunction in salt-sensitive hypertension. 11347859 - New insights into the therapeutic mechanism of action of calcium channel blockers in sa... 2907589 - Amelioration of the hypotensive effect of trypanocidal diamidines by use of heavy solub... 11161799 - Concordance of murine quantitative trait loci for salt-induced hypertension with rat an... 9814619 - Does the sabra hypertension-prone rat represent a model of salt or mineralocorticoid se... 3976749 - An examination of vascular reactivity during pregnancy in the chronic ewe model. 17760219 - Ambulatory blood pressure monitoring: a mean to stratify cardiovascular risk. 2340159 - Autonomic and somatic responses evoked by stimulation of the cerebellar uvula in the co... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Canadian journal of physiology and pharmacology Volume: 81 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 2003 Oct |
Date Detail:
|
Created Date: 2003-11-10 Completed Date: 2004-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: Canada |
Other Details:
|
Languages: eng Pagination: 929-36 Citation Subset: IM |
Affiliation:
|
Laboratoire de Physiologie et de Pharmacologie, Nutrition Préventive Expémentale, Faculté de Médecine et de Pharmacie, Besançcon, France. sylvie.bobillier-chaumont@univ-fcomte.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants / metabolism* Blood Pressure / drug effects Body Weight / drug effects Catalase / metabolism Desoxycorticosterone / pharmacology Drug Administration Schedule Female Glutathione Peroxidase / metabolism Glutathione Reductase / metabolism Heart Rate / drug effects Hypertension / metabolism*, physiopathology Liver / enzymology, metabolism* Male Metallothionein / deficiency, metabolism Mice Mice, Transgenic Myocardium / metabolism, pathology Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 64-85-7/Desoxycorticosterone; 9038-94-2/Metallothionein; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A first-generation map of the turkey genome.
Next Document: Role of the Na+-H+ exchanger (NHE1) in heart muscle function during transient acidosis. A study in p...