Document Detail

Antioxidant status in controlled and uncontrolled hypertension and its relationship to endothelial damage.
MedLine Citation:
PMID:  7853328     Owner:  NLM     Status:  MEDLINE    
Hypertension is associated with an increased risk of atherosclerosis. Free radical oxidative damage has been implicated in the atherogenic process. We measured levels of the antioxidants uric acid, thiols, vitamins C, A and E as well as the total antioxidant capacity in 21 normotensive controls, 22 patients whose hypertension was controlled on drugs and 30 patients with uncontrolled hypertension. Mean BPs in the groups were 125/76, 132/80 and 181/98 mmHg, respectively. When compared with controls, both hypertensive groups had significantly lower serum ascorbic acid (54 +/- 5 vs. 37 +/- 6 vs. 38 +/- 5 mumol/l, P < 0.05) and albumin-corrected thiol levels (9.91 +/- 0.18 vs. 8.69 +/- 0.20 vs. 8.92 +/- 0.19 mumol/g, P < 0.05). The levels of the other antioxidants did not differ significantly between the groups. Levels of von Willebrand factor, a marker of endothelial damage, were correlated with SBP but not with antioxidant status. We conclude that hypertensive subjects have lower levels of the antioxidants vitamin C and thiols and this may reflect greater oxidative consumption. The implications for atherogenesis and endothelial function and integrity in hypertension are discussed.
W Y Tse; S R Maxwell; H Thomason; A Blann; G H Thorpe; M Waite; R Holder
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  8     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  843-9     Citation Subset:  IM    
Hypertension Clinic, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
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MeSH Terms
Analysis of Variance
Antihypertensive Agents / therapeutic use
Antioxidants / metabolism*
Arteriosclerosis / blood*,  etiology
Ascorbic Acid / blood
Biological Markers / blood
Endothelium, Vascular / metabolism*,  pathology
Free Radical Scavengers / blood*
Hypertension / blood*,  drug therapy*,  physiopathology
Middle Aged
Uric Acid / blood
Vitamin A / blood
Vitamin E / blood
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Antihypertensive Agents; 0/Antioxidants; 0/Biological Markers; 0/Free Radical Scavengers; 0/von Willebrand Factor; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 69-93-2/Uric Acid

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