Document Detail

Antioxidant status of bilirubin and uric acid in patients diagnosed with Plasmodium falciparum malaria in Douala.
MedLine Citation:
PMID:  18819658     Owner:  NLM     Status:  MEDLINE    
Oxidative stress and changes in antioxidant status have been implicated in the pathogenesis of malaria. To assess the antioxidant level ofbilirubin and uric acid associated with falciparum malaria infection, 60 untreated patients (30 men and 30 women) in Douala, Cameroon were screened for the study. Sixty five healthy individuals (29 men and 36 women) were used as controls. Total and conjugated bilirubin were calculated using Jendrassik-Grof method while uric acid was determined using Barham-Trinder method. It was observed that total and conjugated bilirubins were significantly (p < 0.001) higher in malaria patients (10.722 +/- 4.043 and 3.627 +/- 1.571 mg L(-1), respectively) when compared to control (6.830 +/- 2.436 and 1.777 +/- 0.729 mg L(-1)) and these bilirubin levels increased significantly with parasite count (p < 0.050). There was also significant increased (p = 0.021) of uric acid in malaria patients (56.262 +/- 13.963 mg L(-1)) compared to controls (49.838 +/- 15.419 mg L(-1)). No significant differences based on sex were observed on uric acid, parasite count, total and conjugated bilirubins in malaria patients. Positive correlations were obtained between parasite count and total bilirubin (r = 0.320, p < 0.050), conjugated bilirubin (r = 0.477, p < 0.001), uric acid (r = 0.060, p > 0.050) and between total and conjugated bilirubin (r = 0.729, p < 0.001). From this study, it has been hypothesized that the augmentation of plasma level ofbilirubin and uric acid could provide more protection against oxidative stress induced by malaria.
Kouam Eric Bertrand; Ndomou Mathieu; Gouado Inocent; Fotso Kuate Honore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  11     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2008-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  1646-9     Citation Subset:  IM    
Department of Molecular Biology and Biotechnology, International Centre of Insect Physiology and Ecology, P.O. Box 30772, Nairobi, Kenya.
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MeSH Terms
Antioxidants / pharmacology*
Bilirubin / blood*
Malaria, Falciparum / blood*,  diagnosis*
Middle Aged
Oxidative Stress
Plasmodium falciparum / metabolism*
Reactive Oxygen Species
Uric Acid / blood*,  chemistry
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 635-65-4/Bilirubin; 69-93-2/Uric Acid

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