Document Detail

Antioxidant property of an active component purified from the leaves of paraquat-tolerant Rehmannia glutinosa.
MedLine Citation:
PMID:  16438803     Owner:  NLM     Status:  MEDLINE    
Acteoside extracted from the leaves of Rehmannia glutinosa was examined to determine the mechanism(s) of its antioxidant properties. The deoxyribose assay system showed that acteoside has a high redox potential as electron donor, which generates hydroxyl radicals in an Fe3+-dependent manner similar to ascorbic acid. However, the antioxidant properties of acteoside differ from those of ascorbic acid in that the superoxide anion-mediated reduction of nitroblue tetrazolium was actively inhibited by acteoside but not by ascorbic acid. Acteoside protected cells against glucose oxidase-mediated cytotoxicity and apoptosis in a dose-dependent manner. In addition, acteoside had immune stimulating effects, as shown by the acteoside-mediated increase in the level of DNA synthesis, viability, and cytokine secretion in mouse splenocytes. Moreover, acteoside inhibited the gelatinolytic activity of MMP proteins in a dose-dependent manner. Considering these results and the fact that acteoside is a water-soluble natural product, acteoside might have potential as a preventative treatment for oxidative stress-mediated diseases and have possibilities in the cosmetic industry.
So-Soon Kim; Young-Ok Son; Jae-Chul Chun; Sung-Eun Kim; Gook-Hyun Chung; Ki-Jun Hwang; Jeong-Chae Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Redox report : communications in free radical research     Volume:  10     ISSN:  1743-2928     ISO Abbreviation:  Redox Rep.     Publication Date:  2005  
Date Detail:
Created Date:  2006-01-27     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9511366     Medline TA:  Redox Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Laboratory of Cell Biology, Department of Orthodontics, Institute of Oral Biosciences, Chonbuk National University, Chonju, Korea.
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MeSH Terms
Antioxidants / metabolism,  pharmacology*
Ascorbic Acid / chemistry
Herbicides / pharmacology
NIH 3T3 Cells
Nitroblue Tetrazolium / pharmacology
Oxidative Stress
Paraquat / pharmacology*
Plant Extracts / metabolism
Plant Leaves / drug effects*
Rehmannia / metabolism*
Superoxides / chemistry
Reg. No./Substance:
0/Antioxidants; 0/Herbicides; 0/Plant Extracts; 11062-77-4/Superoxides; 298-83-9/Nitroblue Tetrazolium; 4685-14-7/Paraquat; 50-81-7/Ascorbic Acid; 533-67-5/Deoxyribose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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