Document Detail

Antioxidant properties of raisins (Vitis vinifera L.).
MedLine Citation:
PMID:  20041785     Owner:  NLM     Status:  MEDLINE    
Currants and sultanas (Vitis vinifera L., Family Vitaceae) are dried vine products produced in Greece and used widely in the Mediterranean diet. We investigated the polar methanol extracts from the raisins for the antiradical activity, polyphenol content, cytotoxicity in peripheral blood mononuclear cells, total glutathione (GSH) levels, oxidized glutathione (GSSG) levels, and inhibition of low-density lipoprotein (LDL) oxidation. Extracts exhibited 1,1-diphenyl-2-picrylhydrazyl scavenging activity and inhibited tert-butylhydroperoxide (tBHP)-induced cytotoxicity, GSH decrease, and LDL oxidation. Fluorescence microscopy revealed the characteristic apoptotic patterns with tBHP and inhibition with the extracts. Elevated levels of total GSH and unaltered levels of GSSG with extract treatment demonstrated the induction of gamma-glutamylcysteine synthetase. The antioxidant activity was correlated to the polyphenolic content. Greek currants and sultanas are suggested as antioxidant components of the Mediterranean basin.
Andriana C Kaliora; Aggeliki M Kountouri; Vaios T Karathanos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  12     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-31     Completed Date:  2010-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1302-9     Citation Subset:  IM    
Department of Science of Dietetics-Nutrition, Harokopio University, Athens, Greece.
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MeSH Terms
Antioxidants / analysis,  pharmacology*
Cell Survival / drug effects
Cells, Cultured
Flavonoids / analysis,  pharmacology
Free Radical Scavengers / metabolism
Glutathione Disulfide / metabolism
Leukocytes, Mononuclear / cytology,  drug effects,  metabolism
Phenols / analysis,  pharmacology
Plant Extracts / analysis,  pharmacology*
Vitis / chemistry*
Reg. No./Substance:
0/Antioxidants; 0/Flavonoids; 0/Free Radical Scavengers; 0/Phenols; 0/Plant Extracts; 0/polyphenols; 27025-41-8/Glutathione Disulfide

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