| Antioxidant potential of specific estrogens on lipid peroxidation. | |
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MedLine Citation:
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PMID: 8408459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary heart disease (CHD) is the leading cause of death in postmenopause. Estrogen administration in postmenopause lowers the risk of CHD by 50%. A variety of estrogen preparations are currently used in postmenopausal hormone replacement therapy. It is unknown, however, if structural differences in the estrogen molecule influence the cardioprotective effects of estrogens. In this communication we have shown that equine estrogens (especially equilin) exhibit higher antioxidant potency (as measured by fatty acids and sterols oxidation) when compared to estrone and estradiol-17 beta. |
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Authors:
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M T Subbiah; B Kessel; M Agrawal; R Rajan; W Abplanalp; Z Rymaszewski |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 77 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-11-12 Completed Date: 1993-11-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1095-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Cincinnati College of Medicine, OH 45267-0540. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cholesterol / metabolism Dose-Response Relationship, Drug Equilin / pharmacology Estradiol / pharmacology Estrogens / pharmacology* Estrone / pharmacology Fatty Acids / metabolism Humans Lipid Peroxidation / drug effects* Lipoproteins, LDL / metabolism Macrophages / drug effects, metabolism Malondialdehyde / metabolism Monocytes / drug effects, metabolism Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Fatty Acids; 0/Lipoproteins, LDL; 474-86-2/Equilin; 50-28-2/Estradiol; 53-16-7/Estrone; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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