Document Detail

Antioxidant intake is associated with semen quality in healthy men.
MedLine Citation:
PMID:  15665024     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We seek to determine whether dietary and supplement intake of specific micronutrients (zinc and folate) and antioxidants (vitamins C, E and beta-carotene) is associated with semen quality. METHODS: Ninety-seven healthy, non-smoking men provided semen and were interviewed. Average daily nutrient intake from food and supplements was derived from a self-administered food frequency questionnaire. Intake levels were summarized as low, moderate and high. Semen volume, sperm concentration, total sperm count, motility, progressive motility and total progressively motile sperm count (TPMS) were measured. RESULTS: After controlling for covariates, a high intake of antioxidants was associated with better semen quality but, in almost all cases, there was no clear dose relationship in that moderate intake groups had the poorest semen quality. For example, positive associations were observed between vitamin C intake and sperm number as reflected in the higher mean count (P=0.04), concentration (P=0.05) and TPMS (P = 0.09); between vitamin E intake and progressive motility (P = 0.04) and TPMS (P = 0.05); and between beta-carotene intake and sperm concentration (P = 0.06) and progressive motility (P = 0.06). Folate and zinc intake were not associated with improved semen quality. CONCLUSIONS: In a convenience sample of healthy non-smoking men from a non-clinical setting, higher antioxidant intake was associated with higher sperm numbers and motility.
B Eskenazi; S A Kidd; A R Marks; E Sloter; G Block; A J Wyrobek
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2005-01-21
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  20     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-24     Completed Date:  2005-06-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1006-12     Citation Subset:  IM    
140 Earl Warren Hall, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Antioxidants / administration & dosage*
Ascorbic Acid / administration & dosage*
Dietary Supplements
Folic Acid / administration & dosage
Infertility, Male / diet therapy,  drug therapy*
Middle Aged
Nutrition Assessment
Semen / drug effects*
Sperm Motility / drug effects*
Vitamin E / administration & dosage
Zinc / administration & dosage
beta Carotene / administration & dosage
Grant Support
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; 7235-40-7/beta Carotene; 7440-66-6/Zinc

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