Document Detail

Antioxidant intake and allergic disease in children.
MedLine Citation:
PMID:  22994346     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Antioxidant intake may reduce the risk of allergic disease by protecting against oxidative tissue damage. Major sources of antioxidants in the Western world are fruits, vegetables (vitamin C, β-carotene, α-tocopherol), meat and milk (selenium, magnesium, zinc). Children may exclude or eat less of some fruits and vegetables due to cross-reactivity between pollen and these foods, complicating assessment of causal relationships.
OBJECTIVE: To investigate the association between dietary antioxidant intake and allergic disease, taking potential reverse causation into account.
METHODS: Data on 2442 8-year-old children from the Swedish birth cohort study BAMSE were analysed. Children with completed parental questionnaires on exposures and health, including a food-frequency questionnaire and who provided a blood sample were included. Associations between antioxidant intake during the past year and current allergic disease were analysed using logistic regression.
RESULTS: An inverse association was observed between intake of β-carotene and rhinitis (OR(adj) , highest vs. lowest quartile, 0.67, 95% CI 0.49-0.93). Magnesium intake was inversely related to asthma (OR(adj) , 0.65, 95% CI 0.42-1.00) and atopic sensitisation (OR(adj) , 0.78, 95% CI 0.61-1.00). Following exclusion of children who avoided certain fruits, vegetables or milk due to allergic symptoms (n = 285), the inverse association remained between magnesium intake and asthma (OR(adj) , 0.58, 95% CI 0.35-0.98), whereas all other associations became non-significant.
CONCLUSION AND CLINICAL RELEVANCE: Diet modifications due to allergy may affect the antioxidant intake and needs to be considered when investigating the relationship between diet and allergic disease. Magnesium intake seems to have a protective effect on childhood asthma.
H Rosenlund; J Magnusson; I Kull; N Håkansson; A Wolk; G Pershagen; M Wickman; A Bergström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  42     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1491-500     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden.
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