Document Detail


Antioxidant enzymes and trace elements in hemodialyzed patients.
MedLine Citation:
PMID:  9363329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antioxidant enzymes together with trace elements in 26 patients with chronic renal failure treated with hemodialysis and 25 healthy subjects were investigated. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSHPx) in plasma and erythrocytes were examined immediately before and after hemodialysis. The results are summarized as follows: 1. A significant decrease in plasma SOD, CAT, and GSHPx and erythrocyte GSHPx were found in patients before hemodialysis. 2. Erythrocyte CAT and GSHPx were significantly lower in the patients after hemodialysis than in the controls. 3. Plasma GSHPx was significantly higher after a single hemodialysis than before hemodialysis. 4. A good correlation between erythrocyte SOD and copper (Cu) in patients before hemodialysis was found. 5. A good correlation of GSHPx in erythrocytes and plasma was found before hemodialysis, whereas an even better correlation was found after hemodialysis. 6. Abnormalities of trace elements were found in hemodialyzed patients. 7. There is indirect evidence for increased oxidizing stress in uremic patients with hemodialysis. Dialysis treatment may improve some abnormalities (e.g., Hb, P), but may also induce some deleterious effects of free radicals or lipid peroxidation.
Authors:
C K Chen; J M Liaw; J G Juang; T H Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  58     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1998-01-08     Completed Date:  1998-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-57     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Jen-Ai Hospital, Taichung, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antioxidants / metabolism*
Blood Chemical Analysis
Catalase / blood
Erythrocytes / chemistry
Female
Glutathione Peroxidase / blood
Humans
Kidney Failure, Chronic / metabolism,  therapy
Male
Middle Aged
Oxidative Stress*
Regression Analysis
Renal Dialysis* / adverse effects
Superoxide Dismutase / blood
Trace Elements / metabolism*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Trace Elements; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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