Document Detail

Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section.
MedLine Citation:
PMID:  12069735     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the antioxidant defense potential of human neonates according to gestational age and mode of delivery. STUDY DESIGN: Four study groups were established, full-term normal spontaneous vaginal delivery (FT-NSVD, n=24), full-term caesarean section (FT-CS, n=19), preterm normal spontaneous vaginal delivery (PT-NSVD, n=15) preterm caesarean section (PT-CS, n=21). The activity of catalase (CAT), glutathion peroxidase (GPX), Cu/Zn superoxide dismutase (Cu/Zn-SOD) were determined from cord blood. Statistical analysis was made by ANOVA. RESULTS: CAT activity was significantly higher in full-term than in preterm newborns. In both the categories, neonates born via caesarean section had significantly lower CAT activities. GPX activity was significantly higher in the FT-NSVD group than in any other group. Cu/Zn-SOD activity was significantly higher in full-term neonates than in preterms and no difference was found related to the mode of delivery. CONCLUSIONS: Prematurity and caesarean section may cause a deficiency of antioxidant defense in human newborn.
George D Georgeson; Barnabás J Szony; Károly Streitman; Ilona Sz Varga; Attila Kovács; László Kovács; Aranka László
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  103     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-18     Completed Date:  2003-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  136-9     Citation Subset:  IM    
Mullikin Medical Center, Artesia, CA 90701, USA.
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MeSH Terms
Antioxidants / metabolism*
Catalase / blood
Cesarean Section*
Delivery, Obstetric
Enzymes / blood*
Glutathione Peroxidase / blood
Infant, Newborn / metabolism
Infant, Premature / metabolism*
Reference Values
Superoxide Dismutase / blood
Reg. No./Substance:
0/Antioxidants; 0/Enzymes; EC; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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