| Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section. | |
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MedLine Citation:
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PMID: 12069735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the antioxidant defense potential of human neonates according to gestational age and mode of delivery. STUDY DESIGN: Four study groups were established, full-term normal spontaneous vaginal delivery (FT-NSVD, n=24), full-term caesarean section (FT-CS, n=19), preterm normal spontaneous vaginal delivery (PT-NSVD, n=15) preterm caesarean section (PT-CS, n=21). The activity of catalase (CAT), glutathion peroxidase (GPX), Cu/Zn superoxide dismutase (Cu/Zn-SOD) were determined from cord blood. Statistical analysis was made by ANOVA. RESULTS: CAT activity was significantly higher in full-term than in preterm newborns. In both the categories, neonates born via caesarean section had significantly lower CAT activities. GPX activity was significantly higher in the FT-NSVD group than in any other group. Cu/Zn-SOD activity was significantly higher in full-term neonates than in preterms and no difference was found related to the mode of delivery. CONCLUSIONS: Prematurity and caesarean section may cause a deficiency of antioxidant defense in human newborn. |
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Authors:
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George D Georgeson; Barnabás J Szony; Károly Streitman; Ilona Sz Varga; Attila Kovács; László Kovács; Aranka László |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 103 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-06-18 Completed Date: 2003-01-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 136-9 Citation Subset: IM |
Affiliation:
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Mullikin Medical Center, Artesia, CA 90701, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism* Catalase / blood Cesarean Section* Delivery, Obstetric Enzymes / blood* Female Glutathione Peroxidase / blood Humans Infant, Newborn / metabolism Infant, Premature / metabolism* Pregnancy Reference Values Superoxide Dismutase / blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Enzymes; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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