Document Detail


Antioxidant enzymatic activities and resistance to oxidative stress in primary and subcultured rat astroglial cells.
MedLine Citation:
PMID:  2756844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The survival of neural tissues depends in part on the balance between the formation of free radicals due to oxidative metabolism and the transformation of the free radicals to non-toxic compounds. Serial subculture of rat glial cells as described here resulted in a decrease of the specific activities of several antioxidant enzymes and a glial specific marker for astrocytes. Thus, there was an increased susceptibility to oxidative stress in cultures by the third passage. These subcultured glial cell cultures may represent a useful model for the study of free radical induced neural damage that may be relevant to CNS trauma and aging.
Authors:
A Vanella; R Avola; D F Condorelli; A Campisi; A Costa; A M Guiffrida Stella; J R Perez-Polo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  7     ISSN:  0736-5748     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-30     Completed Date:  1989-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
Affiliation:
Institute of Biochemistry, University of Catania, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / enzymology*
Catalase / metabolism*
Cell Survival
Cells, Cultured
Free Radicals
Glutathione Peroxidase / metabolism*
Glutathione Reductase / metabolism*
Oxygen Consumption*
Rats
Grant Support
ID/Acronym/Agency:
NS18708/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Free Radicals; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.8.1.7/Glutathione Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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