Document Detail

Antioxidant enzymatic activities and resistance to oxidative stress in primary and subcultured rat astroglial cells.
MedLine Citation:
PMID:  2756844     Owner:  NLM     Status:  MEDLINE    
The survival of neural tissues depends in part on the balance between the formation of free radicals due to oxidative metabolism and the transformation of the free radicals to non-toxic compounds. Serial subculture of rat glial cells as described here resulted in a decrease of the specific activities of several antioxidant enzymes and a glial specific marker for astrocytes. Thus, there was an increased susceptibility to oxidative stress in cultures by the third passage. These subcultured glial cell cultures may represent a useful model for the study of free radical induced neural damage that may be relevant to CNS trauma and aging.
A Vanella; R Avola; D F Condorelli; A Campisi; A Costa; A M Guiffrida Stella; J R Perez-Polo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  7     ISSN:  0736-5748     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-30     Completed Date:  1989-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
Institute of Biochemistry, University of Catania, Italy.
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MeSH Terms
Astrocytes / enzymology*
Catalase / metabolism*
Cell Survival
Cells, Cultured
Free Radicals
Glutathione Peroxidase / metabolism*
Glutathione Reductase / metabolism*
Oxygen Consumption*
Grant Support
Reg. No./Substance:
0/Free Radicals; EC; EC Peroxidase; EC Reductase

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