| Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen. | |
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MedLine Citation:
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PMID: 19124059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidant/antioxidant status, estrogenic/anti-estrogenic activity and gene expression profile were studied in mice fed with Cystus incanus L. (Cistaceae) reach bee pollen from location in Central Croatia's Dalmatia coast and offshore islands. Seven phenolic compounds (out of 13 tested) in bee pollen sample were detected by high performance liquid chromatography (HPLC) analysis. Phenolics detected in C. incanus L. bee pollen belong to flavonol (pinocembrin), flavanols (quercetin, kaempferol, galangin, and isorhamnetin), flavones (chrysin) and phenylpropanoids (caffeic acid). Bee pollen as a food supplement (100mg/kgbw mixed with commercial food pellets) compared to control (commercial food pellets) modulated antioxidant enzymes (AOE) in the mice liver, brain and lysate of erythrocytes and reduced hepatic lipid peroxidation (LPO). Bee pollen induced 25% of anti-estrogenic properties while no estrogenic activity was found. Differential gene expression profile analyses after bee pollen enriched diet identify underexpressed gene Hspa9a, Tnfsf6 (liver) and down-regulated gene expression of Casp 1 and Cc121c (brain) which are important in the apoptosis pathway and chemotaxis. These results indicate that used bee pollen possess a noticable source of compounds with health protective potential and antioxidant activity. |
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Authors:
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Ana Sarić; Tihomir Balog; Sandra Sobocanec; Borka Kusić; Visnja Sverko; Gordana Rusak; Sasa Likić; Dragan Bubalo; Barbara Pinto; Daniela Reali; Tatjana Marotti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-16 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 47 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-11 Completed Date: 2009-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 547-54 Citation Subset: IM |
Affiliation:
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Division of Molecular Medicine, Rudjer Bosković Institute, Bijenicka 54, 10000 Zagreb, Croatia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Bees Brain / metabolism Chromatography, High Pressure Liquid Cistaceae / chemistry* Estrogen Receptor Modulators / pharmacology Estrogens / pharmacology Female Flavonoids / isolation & purification, pharmacology* Gene Expression Profiling Liver / metabolism Mice Mice, Inbred CBA Pollen / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Estrogen Receptor Modulators; 0/Estrogens; 0/Flavonoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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