Document Detail

Antioxidant effect on urinary excretion of malondialdehyde in non-athletes during aerobic training.
MedLine Citation:
PMID:  19838998     Owner:  NLM     Status:  MEDLINE    
Conditions in the body during aerobic exercise increase the level of lipid peroxidation (LP). LP is associated with elevated concentration of modified low-density lipoproteins that are implicated in development of cardiovascular disease. Supplementation with antioxidant vitamin E to athletes at 267 mg (400 IUs) or greater has been reported to reduce levels of LP associated with exercise. Little is currently known about the effects of modest supplementation of vitamin E on previously sedentary adults who initiate an aerobic fitness program. In the present study, sedentary subjects (n = 14) kept 24-hour diet records to establish antioxidant intake of vitamins E and C and collected 24-hour urine samples that were used to determine baseline urinary malondialdehyde (MDA) concentrations, one measure of in vivo LP. No significant differences were noted in the parameters between groups. Seven subjects were randomly selected and supplemented daily with 133 mg (200 IUs) of vitamin E. All subjects participated in moderate-intensity aerobic training for 8 weeks. Post-training, non-supplemented subjects excreted significantly more MDA (p<0.05) and consumed significantly fewer antioxidants than the supplemented group. Vitamin E supplementation appears to suppress elevated LP associated with beginning an aerobic exercise regimen in previously sedentary subjects.
M Hadley; M F Visser; T Vander Steen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  79     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Department of Chemistry and Geology, Minnesota State University, Mankato, Mankato, MN 56001, USA.
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MeSH Terms
Antioxidants / metabolism*
Ascorbic Acid / administration & dosage
Body Height
Body Weight
Diet Records
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Dietary Supplements
Energy Intake
Exercise / physiology*
Heart Rate / physiology
Lipid Peroxidation*
Malondialdehyde / urine*
Oxidative Stress / physiology
Physical Fitness / physiology
Pilot Projects
Single-Blind Method
Vitamin E / administration & dosage,  metabolism*
Young Adult
Reg. No./Substance:
0/Antioxidants; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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