| Antioxidant effect on urinary excretion of malondialdehyde in non-athletes during aerobic training. | |
MedLine Citation:
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PMID: 19838998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conditions in the body during aerobic exercise increase the level of lipid peroxidation (LP). LP is associated with elevated concentration of modified low-density lipoproteins that are implicated in development of cardiovascular disease. Supplementation with antioxidant vitamin E to athletes at 267 mg (400 IUs) or greater has been reported to reduce levels of LP associated with exercise. Little is currently known about the effects of modest supplementation of vitamin E on previously sedentary adults who initiate an aerobic fitness program. In the present study, sedentary subjects (n = 14) kept 24-hour diet records to establish antioxidant intake of vitamins E and C and collected 24-hour urine samples that were used to determine baseline urinary malondialdehyde (MDA) concentrations, one measure of in vivo LP. No significant differences were noted in the parameters between groups. Seven subjects were randomly selected and supplemented daily with 133 mg (200 IUs) of vitamin E. All subjects participated in moderate-intensity aerobic training for 8 weeks. Post-training, non-supplemented subjects excreted significantly more MDA (p<0.05) and consumed significantly fewer antioxidants than the supplemented group. Vitamin E supplementation appears to suppress elevated LP associated with beginning an aerobic exercise regimen in previously sedentary subjects. |
Authors:
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M Hadley; M F Visser; T Vander Steen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Volume: 79 ISSN: 0300-9831 ISO Abbreviation: Int J Vitam Nutr Res Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2009-11-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273304 Medline TA: Int J Vitam Nutr Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 5-13 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Geology, Minnesota State University, Mankato, Mankato, MN 56001, USA. mary.hadley@mnsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / metabolism* Ascorbic Acid / administration & dosage Body Height Body Weight Diet Records Dietary Carbohydrates / administration & dosage Dietary Fats / administration & dosage Dietary Proteins / administration & dosage Dietary Supplements Energy Intake Exercise / physiology* Female Heart Rate / physiology Humans Lipid Peroxidation* Male Malondialdehyde / urine* Oxidative Stress / physiology Physical Fitness / physiology Pilot Projects Questionnaires Single-Blind Method Vitamin E / administration & dosage, metabolism* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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