Document Detail

Antioxidant effect of diphenyl diselenide on oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice.
MedLine Citation:
PMID:  19382129     Owner:  NLM     Status:  MEDLINE    
This study was designed to examine if diphenyl diselenide (PhSe)(2), an organoselenium compound, attenuates oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice. Swiss mice were pre-treated with (PhSe)(2) (5 mg kg(-1) day(-1)) for 7 days. At the 7th day, the animals were submitted to acute physical exercise which consisted of continuous swimming for 20 min. The animals were euthanized 1 and 24 h after the exercise test. The levels of thiobarbituric acid reactive species (TBARS), non-protein thiols (NPSH) and ascorbic acid and the activity of catalase (CAT) were measured in the lungs and skeletal muscle of mice. Glycogen content was determined in the skeletal muscle of mice. Parameters in plasma (urea and creatinine) were determined. The results demonstrated an increase in TBARS levels induced by acute physical exercise in the skeletal muscle and lungs of mice. Animals submitted to exercise showed an increase in non-enzymatic antioxidant defenses (NPSH and ascorbic acid) in the skeletal muscle. In lungs of mice, activity of CAT was increased. (PhSe)(2) protected against the increase in TBARS levels and ameliorated antioxidant defenses in the skeletal muscle and lungs of mice submitted to physical exercise. These results indicate that acute physical exercise caused a tissue-specific oxidative stress in the skeletal muscle and lungs of mice. (PhSe)(2) protected against oxidative damage induced by acute physical exercise in mice.
Marina Prigol; Cristiane Luchese; Cristina Wayne Nogueira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  27     ISSN:  1099-0844     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  England    
Other Details:
Languages:  eng     Pagination:  216-22     Citation Subset:  IM    
Copyright Information:
2009 John Wiley & Sons, Ltd.
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
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MeSH Terms
Antioxidants / pharmacology*
Ascorbic Acid / analysis
Benzene Derivatives / pharmacology*
Catalase / metabolism
Creatinine / blood
Glycogen / analysis
Lung / drug effects*,  metabolism
Muscle, Skeletal / drug effects*,  metabolism
Organoselenium Compounds / pharmacology*
Oxidative Stress / drug effects*
Physical Conditioning, Animal
Thiobarbiturates / analysis
Urea / blood
Reg. No./Substance:
0/Antioxidants; 0/Benzene Derivatives; 0/Organoselenium Compounds; 0/Thiobarbiturates; 1666-13-3/diphenyldiselenide; 50-81-7/Ascorbic Acid; 504-17-6/thiobarbituric acid; 57-13-6/Urea; 60-27-5/Creatinine; 9005-79-2/Glycogen; EC

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