| Antioxidant and cancer cell proliferation inhibition effect of citrus pectin-oligosaccharide prepared by irradiation. | |
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MedLine Citation:
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PMID: 17004892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pectin was dissolved in deionized distilled water (2%, vol/vol) and irradiated at 20 kGy using a Co-60 gamma ray irradiator. The resulting solution was dialyzed and lyophilized. The samples were separated into three groups to estimate their antioxidant and cancer cell proliferation effects: non-irradiated (0 kGy), irradiated (20 kGy), and dialyzed (20 kGy-F, mol wt <10,000) samples. Antioxidant properties of each treatment was tested by a beta-carotene-linoleic acid bleaching assay and electron donating ability and compared for antioxidant index, which indicated that the activity was higher in the order of 20 kGy-F > 20 kGy > 0 kGy. Spleen cell survival effect of the irradiated pectin (20 kGy) and dialyzed (20 kGy-F) samples was higher than the non-irradiated control (0 kGy). The pectins inhibited growth of the cancer cell in the order of 20 kGy- F > 20 kGy > 0 kGy. The Ames test revealed that none of the fractions was mutagenic, and there was no indication of a dose-dependent response for any of the samples. These results suggest that a functional pectin oligosaccharide can be produced by irradiation for the food industry without any chemical treatment. |
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Authors:
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Ho Jin Kang; Cheorun Jo; Joong Ho Kwon; Jun Ho Son; Bong Jeon An; Myung Woo Byun |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 9 ISSN: 1096-620X ISO Abbreviation: J Med Food Publication Date: 2006 |
Date Detail:
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Created Date: 2006-09-28 Completed Date: 2006-11-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 313-20 Citation Subset: IM |
Affiliation:
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Department of Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, KAERI, Jeongeup, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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pharmacology* Biphenyl Compounds Cell Division / drug effects* Cell Line, Tumor Citrus / chemistry* Free Radical Scavengers / chemistry Fruit / chemistry Gamma Rays Humans Linoleic Acid / chemistry, pharmacology Mutagenicity Tests Neoplasms / pathology* Oligosaccharides / pharmacology, radiation effects Oxidation-Reduction Pectins / pharmacology*, radiation effects* Picrates beta Carotene / chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biphenyl Compounds; 0/Free Radical Scavengers; 0/Oligosaccharides; 0/Pectins; 0/Picrates; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 2197-37-7/Linoleic Acid; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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