Document Detail


Antioxidant and antiatherogenic activity of cis-Hinokiresinol from Trapa pseudoincisa.
MedLine Citation:
PMID:  18087806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
cis-Hinokiresinol, also known as (+)-nyasol, was isolated for the first time from an aquatic herbaceous plant, Trapa pseudoincisa NAKAI, via silica gel and octadecyl silica gel column chromatographies. The chemical structure was determined via analyses of the spectroscopic data, including NMR, MS and IR. cis-Hinokiresinol was also found to exhibit antioxidant and antiatherogenic activities. The ICso values for the scavenging activities of cis-hinokiresinol on ABTS cation and superoxide anion radicals were 45.6 and 40.5 microM, respectively. The IC50 values for the inhibitory effects on Lp-PLA2, hACAT1, hACAT2 and LDL-oxidation were 284.7, 280.6, 398.9 and 5.6 microM, respectively.
Authors:
Myoung-Chong Song; Hye-Joung Yang; Myun-Ho Bang; Dae-Keun Kim; Tae-Sook Jeong; Jong-Pyung Kim; Nam-In Baek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of pharmacal research     Volume:  30     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-19     Completed Date:  2008-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1392-7     Citation Subset:  IM    
Affiliation:
Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon 446-701, Korea.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / chemistry,  isolation & purification,  pharmacology*
Atherosclerosis / drug therapy*
Humans
Lignans / chemistry,  isolation & purification,  pharmacology*
Lipoproteins, LDL / metabolism
Lythraceae / chemistry*
Phenols / chemistry,  isolation & purification,  pharmacology*
Phospholipases A2 / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Lignans; 0/Lipoproteins, LDL; 0/Phenols; 17676-24-3/hinokiresinol; EC 3.1.1.4/Phospholipases A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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