Document Detail

Antioxidant, anti-inflammatory, anti-nociceptive activities and composition of Lythrum salicaria L. extracts.
MedLine Citation:
PMID:  17125946     Owner:  NLM     Status:  MEDLINE    
Lythrum salicaria (purple loosestrife) known as "Tibbi hevhulma" in Turkish is used for its several beneficial health effects against as diarrhea, chronic intestinal catarrh, hemorrhoid and eczema in the form of a decoction or a fluid extract and to treat varicose veins, bleeding of the gums, hemorrhoid and eczema, externally. Dried herbal parts of Lythrum salicaria L. (Lythraceae) were sequentially extracted with different solvents such as petroleum ether, ethyl acetate, methanol and 50% aqueous methanol. Water extract of Lythrum salicaria was also prepared under reflux. Antioxidant, anti-inflammatory and anti-nociceptive activities of all the extracts were investigated using in vitro and in vivo methods, respectively. Free radical scavenging activity (1,1-diphenyl-2-picrylhydrazyl, DPPH* assay), iron(III) reductive activity, capacity of the inhibition of linoleic acid peroxidation and MDA formation, anti-nociceptive activity (p-benzoquinone-induced abdominal constriction test) and anti-inflammatory activity (carrageenan-induced hind paw edema model) were used for all the extracts. In addition, the content of total phenolics, flavonoids and flavonols in all the extracts were determined with spectrophotometric methods. Results were compared with reference antioxidants via ascorbic acid, butylated hydroxytoluene, and gallic acid. Qualitative and quantitative compositions of all the extracts were analysed using a HPLC-PDA system. Polar fractions were found to be rich in flavonoids such as isovitexin and isoorientin.
Zeynep Tunalier; Müberra Koşar; Esra Küpeli; Ihsan Caliş; K Hüsnü Can Başer
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-11-27
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  110     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  539-47     Citation Subset:  IM    
Department of Pharmacognosy, Anadolu University, 26470 Eskişehir, Turkey.
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MeSH Terms
Analgesics / chemistry,  pharmacology*
Anti-Inflammatory Agents / chemistry,  pharmacology*
Antioxidants / chemistry,  pharmacology*
Edema / drug therapy
Flavonoids / isolation & purification,  pharmacology
Free Radical Scavengers / chemistry,  pharmacology
Iron / metabolism
Linoleic Acid / metabolism
Lipid Peroxidation / drug effects
Lythrum / chemistry*
Malondialdehyde / metabolism
Medicine, Traditional
Pain / drug therapy
Pain Measurement / drug effects
Phenols / isolation & purification,  pharmacology
Plant Extracts / chemistry,  pharmacology*
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Flavonoids; 0/Free Radical Scavengers; 0/Phenols; 0/Plant Extracts; 2197-37-7/Linoleic Acid; 542-78-9/Malondialdehyde; 7439-89-6/Iron

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