Document Detail


Antioxidant and anti-hyperglycemic activity of polysaccharide isolated from Dendrobium chrysotoxum Lindl.
MedLine Citation:
PMID:  17927899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although polysaccharide is believed to play an important role in the medicinal effect of Dendrobium chrysotoxum Lindl (DCL), its role as an antioxidant and in anti-hyperglycemic induction was not reported. In this study, polysaccharide with molecular weight of approximately 150 kDa, herein named DCLP, was isolated from the stem of DCL, and its antioxidative, hypoglycemic and immune stimulating effects were evaluated using various in vitro and in vivo assay systems. DCLP inhibited hydroxyl radicals (*OH)-mediated deoxyribose degradation by scavenging hydroxyl radicals directly as well as by chelating iron ions. DCLP also showed dose-dependent scavenging activity on superoxide anions (O2*) and offered significant protection (p < 0.001) against glucose oxidasemediated cytotoxicity in Jurkat cells. DCLP had immune stimulating effects, as evidenced by the DCLP-mediated increases in the level of DNA synthesis, viability, and cytokine secretion in mouse lymphocytes. Moreover, oral administration of DCLP produced a significant reduction in blood glucose level in alloxan-induced diabetic mice. These findings suggest that DCLP has a potential utility in treating patients who require enhanced antioxidation, immune function and/or hypoglycemic activity.
Authors:
Yaping Zhao; Young-Ok Son; So-Soon Kim; Yong-Suk Jang; Jeong-Chae Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biochemistry and molecular biology     Volume:  40     ISSN:  1225-8687     ISO Abbreviation:  J. Biochem. Mol. Biol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2008-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702084     Medline TA:  J Biochem Mol Biol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  670-7     Citation Subset:  IM    
Affiliation:
Research Center of Bioactive Materials, Chonbuk National University, Chonju 561-756, Korea.
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MeSH Terms
Descriptor/Qualifier:
Alloxan / toxicity
Animals
Antioxidants / pharmacology*
Cell Survival / drug effects
Cell-Free System / chemistry,  drug effects
Cytokines / metabolism
Dendrobium / chemistry*
Diabetes Mellitus, Experimental / blood,  chemically induced,  prevention & control
Dose-Response Relationship, Drug
Electrophoresis, Polyacrylamide Gel
Free Radical Scavengers / pharmacology
Humans
Hydroxyl Radical / antagonists & inhibitors,  chemistry
Hypoglycemic Agents / pharmacology*
Jurkat Cells
Male
Mice
Mice, Inbred BALB C
Molecular Weight
Plant Extracts / chemistry,  isolation & purification,  pharmacology
Polysaccharides / pharmacology*
Spectroscopy, Fourier Transform Infrared
Superoxides / antagonists & inhibitors,  chemistry
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Cytokines; 0/Free Radical Scavengers; 0/Hypoglycemic Agents; 0/Plant Extracts; 0/Polysaccharides; 11062-77-4/Superoxides; 3352-57-6/Hydroxyl Radical; 50-71-5/Alloxan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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