| Antioxidant and anti-hyperglycemic activity of polysaccharide isolated from Dendrobium chrysotoxum Lindl. | |
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MedLine Citation:
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PMID: 17927899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although polysaccharide is believed to play an important role in the medicinal effect of Dendrobium chrysotoxum Lindl (DCL), its role as an antioxidant and in anti-hyperglycemic induction was not reported. In this study, polysaccharide with molecular weight of approximately 150 kDa, herein named DCLP, was isolated from the stem of DCL, and its antioxidative, hypoglycemic and immune stimulating effects were evaluated using various in vitro and in vivo assay systems. DCLP inhibited hydroxyl radicals (*OH)-mediated deoxyribose degradation by scavenging hydroxyl radicals directly as well as by chelating iron ions. DCLP also showed dose-dependent scavenging activity on superoxide anions (O2*) and offered significant protection (p < 0.001) against glucose oxidasemediated cytotoxicity in Jurkat cells. DCLP had immune stimulating effects, as evidenced by the DCLP-mediated increases in the level of DNA synthesis, viability, and cytokine secretion in mouse lymphocytes. Moreover, oral administration of DCLP produced a significant reduction in blood glucose level in alloxan-induced diabetic mice. These findings suggest that DCLP has a potential utility in treating patients who require enhanced antioxidation, immune function and/or hypoglycemic activity. |
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Authors:
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Yaping Zhao; Young-Ok Son; So-Soon Kim; Yong-Suk Jang; Jeong-Chae Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biochemistry and molecular biology Volume: 40 ISSN: 1225-8687 ISO Abbreviation: J. Biochem. Mol. Biol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-11 Completed Date: 2008-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9702084 Medline TA: J Biochem Mol Biol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 670-7 Citation Subset: IM |
Affiliation:
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Research Center of Bioactive Materials, Chonbuk National University, Chonju 561-756, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan
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toxicity Animals Antioxidants / pharmacology* Cell Survival / drug effects Cell-Free System / chemistry, drug effects Cytokines / metabolism Dendrobium / chemistry* Diabetes Mellitus, Experimental / blood, chemically induced, prevention & control Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Free Radical Scavengers / pharmacology Humans Hydroxyl Radical / antagonists & inhibitors, chemistry Hypoglycemic Agents / pharmacology* Jurkat Cells Male Mice Mice, Inbred BALB C Molecular Weight Plant Extracts / chemistry, isolation & purification, pharmacology Polysaccharides / pharmacology* Spectroscopy, Fourier Transform Infrared Superoxides / antagonists & inhibitors, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Cytokines; 0/Free Radical Scavengers; 0/Hypoglycemic Agents; 0/Plant Extracts; 0/Polysaccharides; 11062-77-4/Superoxides; 3352-57-6/Hydroxyl Radical; 50-71-5/Alloxan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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