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Antioxidant and anti-ageing activities of mycelial polysaccharides from Lepista sordida.
MedLine Citation:
PMID:  23811078     Owner:  NLM     Status:  Publisher    
The intracellular polysaccharides (CLSP) were extracted from Lepista sordida mycelium in submerged culture followed by concentration and ethanol precipitation. The antioxidant activities of CLSP were evaluated both in vitro and in vivo. In vitro antioxidant assay, CLSP had noticeable scavenging activities on superoxide anion, hydroxyl radical and 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical. For antioxidant testing in vivo, different doses of CLSP were orally administrated over a period of 6 weeks in a D-galactose induced aged mice model. As results, CLSP significantly inhibited the formation of malondialdehyde (MDA) and raised the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice brains and serums in a dose-dependent manner. The results provide a reference for large-scale production of CLSP by submerged fermentation and suggested that CLSP had potent antioxidant activity and could be explored as a potential dietary supplement to retard aging and attenuate age-related diseases in humans.
Weiqi Zhong; Ning Liu; Yanguang Xie; Yanming Zhao; Xiao Song; Weiming Zhong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-25
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  -     ISSN:  1879-0003     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-7-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
College of Food Science, Northeast Agricultural University, Mucai Street No. 59, Xiangfang District, Harbin 150030, P. R. China; Key Lab. of Dairy Science, Ministry of Education, Northeast Agricultural University, Mucai Street No. 59, Xiangfang District, Harbin 150030, P. R. China.
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