| Antioxidant activity of butyl- and phenylstannoxanes derived from 2-, 3- and 4-pyridinecarboxylic acids. | |
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MedLine Citation:
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PMID: 20714307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vitro antioxidant activity for 12 stannoxanes derived from Ph(3)SnCl (compounds 1-3), Ph(2)SnCl(2) (compounds 4-6), Bu(3)SnCl (compounds 7-9), and Bu(2)SnCl(2) (compounds 10-12), was assayed qualitatively by the chromatographic profile with 1,1-diphenyl-2-picrylhydrazil (DPPH) method and by two quantitative methods: the DPPH radical scavenging activity and Ferric-Reducing Antioxidant Power (FRAP) assays. The results were compared with those obtained with the starting materials 2-pyridine- carboxylic acid (I), 3-pyridinecarboxylic acid (II) and 4-pyridinecarboxylic acid (III), as well as with standard compounds, such as vitamin C and vitamin E, respectively. The in vitro antiradical activity with DPPH of diphenyltin derivative 5 showed a very similar behavior to vitamin C at a 20 microg/mL concentration, whereas according to the FRAP method, compound 8 was better. This difference is due to the mechanism of the antioxidant process. The Structure-Activity Relationships (SAR) for both methods is also reported. |
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Authors:
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Alicia Corona-Bustamante; Juan Manuel Viveros-Paredes; Angelina Flores-Parra; Ana Lilia Peraza-Campos; Francisco J Martínez-Martínez; María Teresa Sumaya-Martínez; Angel Ramos-Organillo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-09 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 15 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-12-03 Revised Date: 2010-12-15 |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 5445-59 Citation Subset: IM |
Affiliation:
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Facultad de Ciencias Químicas, Universidad de Colima, kilómetro 9 carretera Colima, Coquimatlán, Col. Mexico, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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chemistry,
pharmacology* Biphenyl Compounds / chemistry Chromatography, Thin Layer Fluorescence Recovery After Photobleaching Free Radical Scavengers / chemistry Iron / chemistry Ligands Nicotinic Acids / chemistry* Oxidation-Reduction / drug effects Picrates / chemistry Tin Compounds / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biphenyl Compounds; 0/Free Radical Scavengers; 0/Ligands; 0/Nicotinic Acids; 0/Picrates; 0/Tin Compounds; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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