Document Detail

Antioxidant activity of blood serum and saliva in patients with periodontal disease treated due to epilepsy.
MedLine Citation:
PMID:  18229666     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the study was to estimate the activity of chosen antioxidants in blood serum and saliva in patients with periodontal disease treated due to epilepsy. MATERIAL AND METHODS: Twenty-five epileptics and fifteen control persons were involved in the study. The activity of selected endogenous antioxidants were determined by spectrophotometric assay. Concentrations of vitamin A and vitamin E were measured using liquid chromatography. RESULTS: The analysis of the serum and saliva from patients with overgrown gingiva revealed: reduced activity of superoxide dismutase, glutathione peroxidase and glutathione reductase, elevated lipid peroxides, and decreased concentration of ascorbic acid and alpha-tocopherol. All values were statistically significant. CONCLUSIONS: Our results indicate on the oxidant-antioxidant disturbances in epileptic patients, which can play an important role in the pathomechanism of periodontal disease in these persons. Further studies on the role of antioxidants in patients with epilepsy treated with antiepileptic drugs and afflicted with gingival hyperplasia will be continued.
H Sobaniec; W Sobaniec; K Sendrowski; S Sobaniec; M Pietruska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in medical sciences     Volume:  52 Suppl 1     ISSN:  1896-1126     ISO Abbreviation:  Adv Med Sci     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-03-04     Revised Date:  2008-05-15    
Medline Journal Info:
Nlm Unique ID:  101276222     Medline TA:  Adv Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  204-6     Citation Subset:  IM    
Department of Pediatric Neurology and Rehabilitation, Medical University of Białystok, Poland.
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MeSH Terms
Antioxidants / analysis*,  metabolism*
Ascorbic Acid / analysis,  blood
Epilepsy / blood,  complications*
Lipid Peroxides / analysis,  blood
Middle Aged
Periodontal Diseases / blood,  etiology*
Saliva / chemistry*
Vitamin E / analysis,  blood
Reg. No./Substance:
0/Antioxidants; 0/Lipid Peroxides; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

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