| Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. | |
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MedLine Citation:
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PMID: 10496414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Olive oil contains several phenolic compounds with antioxidant activity, whose levels depend strongly on the kind of cultivar grown, fruit ripening effects and the oil extraction process. Therefore, the beneficial effects exerted by olive oil consumption on the resistance of low density lipoproteins (LDLs) to oxidation depend not only on an increased intake of mono-unsaturated fatty acids (e.g. oleate) which are less prone to oxidation, but also phenolic antioxidants. The aim of this study was to analyze in vitro effects exerted on the oxidative modification of Cu-stimulated human LDL by two olive oil biophenols, i.e. 3,4-dihydroxyphenylethanol-elenolic acid (3,4-DHPEA-EA) and protocatecuic acid. These compounds have not been investigated in as much detail as the better-known olive oil biophenols - such as tyrosol (p-HPEA), o-coumaric acid, vanillic acid, caffeic acid, oleuropein and 3,4-dihydroxyphenylethanol (3,4-DHPEA). Modification of LDL was tested by measuring the formation of intermediate and end products of lipid peroxidation such as conjugated dienes, lipid hydroperoxides, cholesterol and cholesteryl ester oxides, as well as studying the decrease in oxidizable substrates like polyunsaturated fatty acids. In addition, the increase in LDL negative charges was evaluated. The results demonstrate the two-tested olive oil biophenols show high antioxidant activities. In particular, protocatecuic acid and 3,4-DHPEA-EA show an antioxidant activity comparable with that of caffeic acid, oleuropein and 3,4-DHPEA. They are not only able to retard lipid peroxidation, but also to reduce the extent of its activity. |
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Authors:
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R Masella; A Cantafora; D Modesti; A Cardilli; L Gennaro; A Bocca; E Coni |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Redox report : communications in free radical research Volume: 4 ISSN: 1351-0002 ISO Abbreviation: Redox Rep. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-10-26 Completed Date: 1999-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9511366 Medline TA: Redox Rep Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 113-21 Citation Subset: IM |
Affiliation:
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Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanità, Rome, Italy. e.coni@iss.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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isolation & purification,
pharmacology* Arachidonic Acid / analysis Cholesterol / analysis Fatty Acids / analysis Humans Hydroxybenzoic Acids / isolation & purification, pharmacology* Linoleic Acid / analysis Lipid Peroxides / analysis* Lipoproteins, LDL / blood*, drug effects, isolation & purification Phenols / isolation & purification, pharmacology* Plant Oils / chemistry*, pharmacology Pyrans / isolation & purification, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/3,4-dixydroxyphenylethanol elenolic acid; 0/Antioxidants; 0/Fatty Acids; 0/Hydroxybenzoic Acids; 0/Lipid Peroxides; 0/Lipoproteins, LDL; 0/Phenols; 0/Plant Oils; 0/Pyrans; 0/oxidized low density lipoprotein; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol; 8001-25-0/olive oil; 99-50-3/protocatechuic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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