Document Detail


Antioxidant activities and oxidative stress byproducts in human hypertension.
MedLine Citation:
PMID:  12707286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective was to study oxidative status, antioxidant activities, and reactive oxygen species byproducts in whole blood and mononuclear peripherals cells and their relationship with blood pressure. Sixty-six hypertensive patients and 16 normotensive volunteers as a control group were studied. In both, whole blood and peripheral mononuclear cells oxidized/reduced glutathione ratio and malondialdehyde was significantly higher, and the activity of superoxide dismutase, catalase, and glutathione peroxidase was significantly lower in hypertensive patients when compared with normal subjects. The content of damaged base 8-oxo-2'-deoxyguanosine in nuclear and mitochondrial deoxyribonucleoproteins of hypertensive subjects was also significantly higher than that of the normotensive control subjects. No differences in these measurements were found among hypertensive subjects grouped in tertiles of 24-hour average mean blood pressure or between "white-coat" and established hypertensive subjects. Furthermore, no relationship was observed between the average of 24-hour mean blood pressure and oxidized/reduced glutathione ratio, reactive oxygen species byproducts, malondialdehide, or genomic 8-oxo-2'-deoxyguanosine. In whole blood and in mononuclear cells from hypertensive subjects, there was an increase in oxidative stress and a reduction in the activity of antioxidant mechanisms that appeared to be independent of the blood pressure values.
Authors:
Josep Redón; Maria R Oliva; Carmen Tormos; Vicente Giner; Javier Chaves; Antonio Iradi; Guillermo T Sáez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-04-21
Journal Detail:
Title:  Hypertension     Volume:  41     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-05     Completed Date:  2003-06-09     Revised Date:  2008-01-22    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1096-101     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, Medical School, University of Valencia, Avda Blasco Ibañez 17, 46010 Valencia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / metabolism*
Blood Pressure / physiology
Catalase / blood
DNA / genetics,  metabolism
DNA, Mitochondrial / genetics,  metabolism
Deoxyguanosine / analogs & derivatives*,  genetics,  metabolism
Female
Glutathione / blood
Glutathione Disulfide / blood
Glutathione Peroxidase / blood
Humans
Hypertension / blood*,  genetics,  physiopathology
Male
Malondialdehyde / blood
Middle Aged
Oxidative Stress*
Reactive Oxygen Species / blood*
Superoxide Dismutase / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 0/DNA, Mitochondrial; 0/Reactive Oxygen Species; 27025-41-8/Glutathione Disulfide; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; 88847-89-6/8-oxo-7-hydrodeoxyguanosine; 9007-49-2/DNA; 961-07-9/Deoxyguanosine; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase
Comments/Corrections
Comment In:
Hypertension. 2004 Feb;43(2):e7-8; author reply e7-8   [PMID:  14756130 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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