Document Detail

Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents.
MedLine Citation:
PMID:  20600528     Owner:  NLM     Status:  MEDLINE    
Leaf of Salvia miltiorrhiza Bunge, the waste part during the root harvest, is rich in health-promoting phenolics and is a novel resource of natural antioxidants. The acetone and methanol extracts of leaves (AL and ML, respectively) of S. miltiorrhiza were evaluated by various in vitro antioxidant assays. The total phenolic contents of AL and ML were 39.0+/-1.13 and 54.3 +/-1.1mg gallic acid equivalents/g extract tested, respectively. EC(50) of ML was 7.0+/-0.28 microg/mL in DPPH radical scavenging assay and 246.5 +/-10.35 microg/mL in superoxide radical quenching assay. It was also found that ML has prominent effects on the inhibition of linoleic acid oxidation (93.2%), which was equivalent to the positive control, butylated hydroxytoluene (BHT, p>0.05), and was significantly higher than α-tocopherol (VE, p<0.05). The reducing power of leaf extracts was as strong as roots (p>0.05). HPLC and correlation analysis show that salvianolic acid B and rosmarinic acid constitute the most abundant phenolic compounds. They are the major contributors to antioxidant activities. The results suggested that S. miltiorrhiza leaves could be considered as a new potential source of natural phenolic antioxidants for food, pharmaceutical, cosmetics or nutraceutical industries.
Yuan Zhang; Xing Li; Zhezhi Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-30
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2656-62     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
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MeSH Terms
Antioxidants / chemistry,  pharmacology*
Benzofurans / pharmacology
Chromatography, High Pressure Liquid
Cinnamates / pharmacology
Depsides / pharmacology
Ferric Compounds / chemistry
Indicators and Reagents
Phenols / chemistry,  pharmacology*
Plant Extracts / chemistry,  pharmacology
Plant Leaves / chemistry
Plant Roots / chemistry
Reducing Agents / chemistry
Salvia miltiorrhiza / chemistry*
Spectrophotometry, Ultraviolet
beta Carotene / chemistry,  pharmacology
Reg. No./Substance:
0/Antioxidants; 0/Benzofurans; 0/Cinnamates; 0/Depsides; 0/Ferric Compounds; 0/Indicators and Reagents; 0/Phenols; 0/Plant Extracts; 0/Reducing Agents; 0/Solvents; 115939-25-8/salvianolic acid B; 537-15-5/rosmarinic acid; 67-56-1/Methanol; 67-64-1/Acetone; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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