| Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents. | |
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MedLine Citation:
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PMID: 20600528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leaf of Salvia miltiorrhiza Bunge, the waste part during the root harvest, is rich in health-promoting phenolics and is a novel resource of natural antioxidants. The acetone and methanol extracts of leaves (AL and ML, respectively) of S. miltiorrhiza were evaluated by various in vitro antioxidant assays. The total phenolic contents of AL and ML were 39.0+/-1.13 and 54.3 +/-1.1mg gallic acid equivalents/g extract tested, respectively. EC(50) of ML was 7.0+/-0.28 microg/mL in DPPH radical scavenging assay and 246.5 +/-10.35 microg/mL in superoxide radical quenching assay. It was also found that ML has prominent effects on the inhibition of linoleic acid oxidation (93.2%), which was equivalent to the positive control, butylated hydroxytoluene (BHT, p>0.05), and was significantly higher than α-tocopherol (VE, p<0.05). The reducing power of leaf extracts was as strong as roots (p>0.05). HPLC and correlation analysis show that salvianolic acid B and rosmarinic acid constitute the most abundant phenolic compounds. They are the major contributors to antioxidant activities. The results suggested that S. miltiorrhiza leaves could be considered as a new potential source of natural phenolic antioxidants for food, pharmaceutical, cosmetics or nutraceutical industries. |
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Authors:
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Yuan Zhang; Xing Li; Zhezhi Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-30 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 2656-62 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetone Antioxidants / chemistry, pharmacology* Benzofurans / pharmacology Chromatography, High Pressure Liquid Cinnamates / pharmacology Depsides / pharmacology Ferric Compounds / chemistry Indicators and Reagents Methanol Phenols / chemistry, pharmacology* Plant Extracts / chemistry, pharmacology Plant Leaves / chemistry Plant Roots / chemistry Reducing Agents / chemistry Salvia miltiorrhiza / chemistry* Solvents Spectrophotometry, Ultraviolet beta Carotene / chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Benzofurans; 0/Cinnamates; 0/Depsides; 0/Ferric Compounds; 0/Indicators and Reagents; 0/Phenols; 0/Plant Extracts; 0/Reducing Agents; 0/Solvents; 115939-25-8/salvianolic acid B; 537-15-5/rosmarinic acid; 67-56-1/Methanol; 67-64-1/Acetone; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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