| Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis. | |
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MedLine Citation:
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PMID: 21085043 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : Exercise increases the production of reactive oxygen species (ROS) in skeletal muscle, and athletes often consume antioxidant supplements in the belief they will attenuate ROS-related muscle damage and fatigue during exercise. However, exercise-induced ROS may regulate beneficial skeletal muscle adaptations, such as increased mitochondrial biogenesis. We therefore investigated the effects of long-term antioxidant supplementation with vitamin E and α-lipoic acid on changes in markers of mitochondrial biogenesis in the skeletal muscle of exercise-trained and sedentary rats. METHODS: : Male Wistar rats were divided into four groups: 1) sedentary control diet, 2) sedentary antioxidant diet, 3) exercise control diet, and 4) exercise antioxidant diet. Animals ran on a treadmill 4 d·wk at ∼70%V˙O2max for up to 90 min·d for 14 wk. RESULTS: : Consistent with the augmentation of skeletal muscle mitochondrial biogenesis and antioxidant defenses, after training there were significant increases in peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) messenger RNA (mRNA) and protein, cytochrome C oxidase subunit IV (COX IV) and cytochrome C protein abundance, citrate synthase activity, Nfe2l2, and SOD2 protein (P < 0.05). Antioxidant supplementation reduced PGC-1α mRNA, PGC-1α and COX IV protein, and citrate synthase enzyme activity (P < 0.05) in both sedentary and exercise-trained rats. CONCLUSIONS: : Vitamin E and α-lipoic acid supplementation suppresses skeletal muscle mitochondrial biogenesis, regardless of training status. |
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Authors:
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Natalie A Strobel; Jonathan M Peake; Aya Matsumoto; Susan A Marsh; Jeff S Coombes; Glenn D Wadley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 43 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1017-24 Citation Subset: IM; S |
Affiliation:
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1School of Human Movement Studies, The University of Queensland, St. Lucia, Queensland, AUSTRALIA; 2Program in Nutrition and Exercise Physiology, Washington State University, Spokane, WA; 3Department of Physiology, The University of Melbourne, Parkville, Victoria, AUSTRALIA; and 4Centre for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, AUSTRALIA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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