| Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration. | |
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MedLine Citation:
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PMID: 21466381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abstract Many acute and chronic effects of ionizing radiation are mediated by reactive oxygen species and reactive nitrogen species, which deplete antioxidant stores, leading to cellular apoptosis, stem cell depletion and accelerated aging. C57BL/6NHsd mice receiving intravenous MnSOD-PL prior to 9.5 Gy total-body irradiation (TBI) show increased survival from the acute hematopoietic syndrome, and males demonstrated improved long-term survival (Epperly et al., Radiat. Res. 170, 437-444, 2008). We evaluated the effect of an antioxidant-chemopreventive diet compared to a regular diet on long-term survival in female mice. Twenty-four hours before the LD(50/30) dose of 9.5 Gy TBI, subgroups of mice were injected intravenously with MnSOD-PL (100 μg plasmid DNA in 100 μl of liposomes). Mice on either diet treated with MnSOD-PL showed decreased death after irradiation compared to irradiated mice on the house diet alone (P = 0.031 for the house diet plus MnSOD-PL or 0.015 for antioxidant diet plus MnSOD-PL). The mice on the antioxidant-chemoprevention diet alone or with MnSOD-PL that survived 30 days after irradiation had a significant increase in survival compared to mice on the regular diet (P = 0.04 or 0.01, respectively). In addition, mice treated with MnSOD-PL only and surviving 30 days after radiation also had increased survival compared to those on the regular diet alone (P = 0.02). Survivors of acute ionizing radiation damage have ameliorated life shortening if they are fed an antioxidant-chemopreventive diet. |
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Authors:
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Michael W Epperly; Hong Wang; Jeffrey A Jones; Tracy Dixon; Carlos A Montesinos; Joel S Greenberger |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-05 |
Journal Detail:
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Title: Radiation research Volume: 175 ISSN: 1938-5404 ISO Abbreviation: Radiat. Res. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-26 Completed Date: 2011-07-27 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
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Languages: eng Pagination: 759-65 Citation Subset: IM; S |
Affiliation:
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Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / administration & dosage* Diet Dietary Supplements Female Lethal Dose 50 Liposomes Mice Mice, Inbred C57BL Plasmids Radiation-Protective Agents / administration & dosage* Superoxide Dismutase / administration & dosage* Whole-Body Irradiation* |
| Grant Support | |
ID/Acronym/Agency:
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U19 AI068021-01/AI/NIAID NIH HHS; U19A1068021//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Liposomes; 0/Radiation-Protective Agents; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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